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Herbal Preparation-induced Liver Injury

Ahn BM

  • KMID: 1113354
  • Korean J Gastroenterol.
  • 2004 Sep;44(3):113-125.
Recently the use of herbal preparations as remedies for various medical conditions, has been rapidly increasing in Korea. In our previous study, 38.9% of patients with chronic liver disease were...
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Liver Transplantation for Acute Toxic Hepatitis due to Herbal Medicines and Preparations

Sohn CH, Cha MI, Oh BJ, Yeo WH, Lee JH, Kim W, Lim KS

  • KMID: 2203440
  • J Korean Soc Clin Toxicol.
  • 2008 Dec;6(2):110-116.
PURPOSE: Acute toxic hepatitis is a common cause of acute liver failure (ALF). We investigated the causes, clinical manifestation, and outcomes of ALF patients who underwent liver transplantation due to...
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Cardiac Toxicities Associated with Herbal Remedies

Jung WJ, Kim H, Cha YS, Kim OH, Cha KC, Lee KH, Hwang SO

  • KMID: 1437673
  • J Korean Soc Clin Toxicol.
  • 2012 Jun;10(1):1-7.
PURPOSE: Herbal preparations have long been used for medical purposes by traditional cultures, and their use is increasing in modern societies. However, many herbal agents produce specific cardiovascular toxicities in...
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Unresolved Issues of Drug-Induced Liver Injury

Kim DJ

  • KMID: 2263941
  • Korean J Med.
  • 2011 Jul;81(1):50-52.
Liver injury due to prescription and nonprescription medications is a growing medical, scientific, and public health problem. Worldwide, the estimated annual incidence rate of Drug-induced liver injury (DILI) is 13.9-24.0...
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Sudden Sensorineural Hearing Loss

Im GJ, Park E

Sudden sensorineural hearing loss (SSNHL) is defined as a sensorineural hearing loss of at least 30 dB in 3 consecutive speech frequencies that occurred within the previous 3 days. In...
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Protective Effects of Geniposide and Genipin against Hepatic Ischemia/Reperfusion Injury in Mice

Kim J, Kim HY, Lee SM

  • KMID: 1502515
  • Biomol Ther.
  • 2013 Mar;21(2):132-137.
Geniposide is an active product extracted from the gardenia fruit, and is one of the most widely used herbal preparations for liver disorders. This study examined the cytoprotective properties of...
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Clinical Features of Drug-induced Liver Injury According to Etiology

Lee BM, Lee WC, Jang JY, Ahn P, Kim JN, Jeong SW, Park EJ, Lee SH, Kim SG, Cha SW, Kim YS, Cho YD, Kim HS, Kim BS

Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according...
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Simultaneous Determination of Four Compounds from Artemisia capillaris using High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD) and Their Quantitative Study in Artemisia Genus

Ko K, Hong IK, Cho HJ, Kim YH, Yang H

Artemisia capillaris Thunb. (Compositae) is a native herb of East Asian countries and has used for the treatment of jaundice, high liver fever, and digestive diseases for a long time,...
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Simultaneous Analysis of Four Standards of The Herbal Formula, DF-02, of Ephedra intermedia and Rheum palmatum, using by High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD)

Choi SY, Jeong B, Jang HS, Lee J, Kwon YS, Yoon Y, Shin SS, Yang H

The herbal formula, DF-02, consisting of Ephedra intermedia and Rheum palmatum are used for the treatment of the metabolic diseases such as obesity and liver fibrosis in Korean local clinics....
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Quantitative Analysis of Metal Contents in Korean Herbs and Herbal Products to Give Advice for Metal Allergic Patient

Choi MJ, Byun JY, Choi HY, Choi YW

BACKGROUND: Herbs have been used worldwide as complementary and alternative medicines. In Korea, herbs for medical purpose are strictly controlled by the Korea Food and Drug Administration (KFDA). But it...
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Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb

Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, Kim HJ, Kim TH, Jung WT, Lee OJ, Lee JS, Shim SG

  • KMID: 2284241
  • Gut Liver.
  • 2011 Dec;5(4):493-499.
BACKGROUND/AIMS: Complementary medicines, including herbal preparations and nutritional supplements, are widely used without prescriptions. As a result, there has been growing interest in the risk of hepatotoxicity with these agents....
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Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Kim ER, Min BH, Lee TH, Son M, Rhee PL

  • KMID: 1792361
  • Gut Liver.
  • 2014 Jul;8(4):388-393.
BACKGROUND/AIMS: DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Corydalis tuber. The aim of this study was to evaluate the effect of DA-9701...
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HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide

Shin NR, Kim SH, Ko JW, Park SH, Lee IC, Ryu JM, Kim JC, Shin IS

HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse...
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Lack of efficacy of a herbal preparation (RCM-102) for seasonal allergic rhinitis: a double blind, randomised, placebo-controlled trial

Lenon GB, Li CG, Da Costa C, Thien FC, Shen Y, Xue CC

BACKGROUND: A herbal preparation, known as RMIT Chinese Medicine 102 (RCM-102) consisting of eight herbs which demonstrates inhibition of the release of key inflammatory mediators associated with seasonal allergic rhinitis...
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Prevalence and Risk Factors of Esophageal Candidiasis in Healthy Individuals: A Single Center Experience in Korea

Choi JH, Lee CG, Lim YJ, Kang HW, Lim CY, Choi JS

PURPOSE: Esophageal candidiasis (EC) is the most frequent opportunistic fungal infection in immunocompromised host. However, we have found EC in healthy individuals through esophagogastroduodenoscopy (EGD). The aim of this study...
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Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats

Lee SP, Lee KN, Lee OY, Lee HL, Jun DW, Yoon BC, Choi HS, Hwang SJ, Lee SE

  • KMID: 1774540
  • Gut Liver.
  • 2014 Mar;8(2):140-147.
BACKGROUND/AIMS: DA-9701, a standardized extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that exhibits an analgesic effect on the abdomen. We investigated whether DA-9701 affects visceral...
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Requirement of Metabolic Activation for Estrogenic Activity of Pueraria mirifica

Lee YS, Park JS, Cho SD, Son JK, Cherdshewasart W, Kang KS

  • KMID: 1097343
  • J Vet Sci.
  • 2002 Dec;3(4):273-277.
A wide range of chemicals derived from plant and human-made xenobiotics are reported to have hormonal activities. The present study was performed to examine the estrogenic effect of Kwao Keur,...
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Antitumor activity of spinasterol isolated from Pueraria roots

Jeon GC, Park MS, Yoon DY, Shin CH, Sin HS, Um SJ

  • KMID: 755749
  • Exp Mol Med.
  • 2005 Apr;37(2):111-120.
We purified phytoestrogens from Pueraria root (Pueraria mirifica from Thailand and Pueraria lobata from Korea), which is used as a rejuvenating folk medicine in Thailand and China. Dried, powdered plant...
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Effects of Ylang-Ylang Essential Oil on the Relaxation of Rat Bladder Muscle in vitro and White Rabbit Bladder in vivo

Kim HJ, Yang HM, Kim DH, Kim HG, Jang WC, Lee YR

Current and primary treatment modality in overactive bladder includes the administration of anticholinergics. The demand for new agents has been rising since anticholinergics have proven to come with many side...
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Matricaria chamomilla CH12 decreases handling stress in Nelore calves

Reis LS, Pardo PE, Oba E, Kronka SN, Frazatti-Gallina NM

Matricaria chamomilla CH12 is a phytotherapeutic or homeopathic product, which has been used to reduce stress. Here, we examined its effect on preventing handling stress in bovines. Sixty Nelore calves were randomly distributed into...
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