Gut Liver.  2014 Jul;8(4):388-393.

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

• Kim ER
• Min BH
• Lee TH
• Son M
• Rhee PL

Abstract

BACKGROUND/AIMS
DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Corydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model.
METHODS
Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6 weeks after birth, CRD was applied to these rats with a pressure of 20 to 90 mm Hg, and changes in the mean arterial pressure (MAP) were measured at baseline (i.e., without any drug administration) and after the administration of different doses of DA-9701.
RESULTS
In the absence of DA-9701, the MAP changes after CRD were significantly higher in the CI group than in the control group at all applied pressures. In the control group, MAP changes after CRD were not significantly affected by the administration of DA-9701. In the CI group, however, the administration of DA-9701 resulted in a significant decrease in MAP changes after CRD. The administration of DA-9701 at a dose of 1.0 mg/kg produced a more significant decrease in MAP changes than the 0.3 mg/kg dose.
CONCLUSIONS
The administration of DA-9701 resulted in a significant increase in pain threshold in rats with CRD-induced visceral hypersensitivity.

Keyword

DA-9701; Colorectal distension; Visceral hypersensitivity; Gastrointestinal diseases

MeSH Terms

Analgesics/administration & dosage/*pharmacology
Animals
Arterial Pressure/drug effects
Colon, Descending/physiology
Dilatation/methods
Gastrointestinal Agents/administration & dosage/*pharmacology
Male
Pain Threshold/drug effects
Plant Preparations/administration & dosage/*pharmacology
Rats, Sprague-Dawley
Visceral Pain/physiopathology/*prevention & control
Analgesics
Gastrointestinal Agents
Plant Preparations