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Effect of Sildenafil on Neuropathic Pain and Hemodynamics in Rats

Huang LJ, Yoon MH, Choi JI, Kim WM, Lee HG, Kim YO

PURPOSE: The inhibition of phosphodiesterase 5 produces an antinociception through the increase of cyclic guanosine monophosphate (cGMP), and increasing cGMP levels enhance the release of gamma-aminobutyric acid (GABA). Furthermore, this...
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Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

Kim ER, Min BH, Lee TH, Son M, Rhee PL

  • KMID: 1792361
  • Gut Liver.
  • 2014 Jul;8(4):388-393.
BACKGROUND/AIMS: DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Corydalis tuber. The aim of this study was to evaluate the effect of DA-9701...
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Interaction of Morphine and Selective Serotonin Receptor Inhibitors in Rats Experiencing Inflammatory Pain

Lee BS, Jun IG, Kim SH, Park JY

Citalopram and paroxetine are selective serotonin reuptake inhibitors and also have antinociceptive effects. We investigated the antiallodynic and antihyperalgesic effects of intrathecally administered morphine, citalopram, paroxetine, and combinations thereof, in...
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