- Withdrawal: Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model
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Han SH, Kim SJ, Yun YW, Nam SY, Lee HJ, Lee BJ
- KMID: 2459312
- Lab Anim Res.
- 2018 Dec;34(4):329-329.
- doi: 10.5625/lar.2018.34.4.329
The reason why the author withdraw the paper is a controversy on intellectual property rights between JIBiopharm Inc. and Hoseo University. -
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- Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea
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Nam H, Kim YY, Kim B, Yoon WK, Kim HC, Suh JG
- KMID: 2459310
- Lab Anim Res.
- 2018 Dec;34(4):311-316.
- doi: 10.5625/lar.2018.34.4.311
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and... -
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- A comparison of metabolomic changes in type-1 diabetic C57BL/6N mice originating from different sources
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Lee S, Kwak JH, Kim SH, Yun J, Cho JY, Kim K, Hwang D, Jung YS
- KMID: 2459300
- Lab Anim Res.
- 2018 Dec;34(4):232-238.
- doi: 10.5625/lar.2018.34.4.232
Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed... -
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- CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
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Lee H, Kim JI, Park JS, Roh JI, Lee J, Kang BC, Lee HW
- KMID: 2459306
- Lab Anim Res.
- 2018 Dec;34(4):279-287.
- doi: 10.5625/lar.2018.34.4.279
Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various... -
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- Growing pigs developed different types of diabetes induced by streptozotocin depending on their transcription factor 7-like 2 gene polymorphisms
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Tu CF, Hsu CY, Lee MH, Jiang BH, Guo SF, Lin CC, Yang TS
- KMID: 2459294
- Lab Anim Res.
- 2018 Dec;34(4):185-194.
- doi: 10.5625/lar.2018.34.4.185
The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in... -
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- In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7
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Hong SS, Lee HA, Kim JY, Jeong JW, Shim JJ, Lee JL, Sim JH, Chung Y, Kim O
- KMID: 2459298
- Lab Anim Res.
- 2018 Dec;34(4):216-222.
- doi: 10.5625/lar.2018.34.4.216
The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated... -
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- Mouse models of breast cancer in preclinical research
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Park MK, Lee CH, Lee H
- KMID: 2459291
- Lab Anim Res.
- 2018 Dec;34(4):160-165.
- doi: 10.5625/lar.2018.34.4.160
Breast cancer remains the second leading cause of cancer death among woman, worldwide, despite advances in identifying novel targeted therapies and the development of treating strategies. Classification of clinical subtypes... -
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- Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis
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Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW
- KMID: 2459303
- Lab Anim Res.
- 2018 Dec;34(4):257-263.
- doi: 10.5625/lar.2018.34.4.257
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of... -
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- Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice
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Kang MJ, Choi JA, Choi JH, Jang AR, Park JY, Ahn JH, Lee TS, Kim DY, Park JH
- KMID: 2459308
- Lab Anim Res.
- 2018 Dec;34(4):295-301.
- doi: 10.5625/lar.2018.34.4.295
Nucleotide-binding domain 1 (Nod1) is a cytosolic receptor that is responsible for the recognition of a bacterial peptidoglycan motif containing meso-diaminophimelic acid. In this study, we sought to identify the... -
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- Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats
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Kim JE, Kang MJ, Choi JY, Park JJ, Lee MR, Song BR, Kim HR, Park JW, Choi HJ, Bae SJ, Hwang DY
- KMID: 2459299
- Lab Anim Res.
- 2018 Dec;34(4):223-231.
- doi: 10.5625/lar.2018.34.4.223
Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts... -
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- CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice
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Kim JI, Park JS, Kwak J, Lim HJ, Ryu SK, Kwon E, Han KM, Nam KT, Lee HW, Kang BC
- KMID: 2459309
- Lab Anim Res.
- 2018 Dec;34(4):302-310.
- doi: 10.5625/lar.2018.34.4.302
CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits... -
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- Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
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Kim H, Kim M, Im SK, Fang S
- KMID: 2459290
- Lab Anim Res.
- 2018 Dec;34(4):147-159.
- doi: 10.5625/lar.2018.34.4.147
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as... -
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- Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes
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Nam SM, Kwon HJ, Kim W, Kim JW, Hahn KR, Jung HY, Kim DW, Yoo DY, Seong JK, Hwang IK, Yoon YS
- KMID: 2459293
- Lab Anim Res.
- 2018 Dec;34(4):176-184.
- doi: 10.5625/lar.2018.34.4.176
In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in... -
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- CRISPR/Cas9-mediated knockout of Rag-2 causes systemic lymphopenia with hypoplastic lymphoid organs in FVB mice
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Kim JI, Park JS, Kim H, Ryu SK, Kwak J, Kwon E, Yun JW, Nam KT, Lee HW, Kang BC
- KMID: 2459292
- Lab Anim Res.
- 2018 Dec;34(4):166-175.
- doi: 10.5625/lar.2018.34.4.166
Recombination activating gene-2 (RAG-2) plays a crucial role in the development of lymphocytes by mediating recombination of T cell receptors and immunoglobulins, and loss of RAG-2 causes severe combined immunodeficiency... -
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- Comparison of the anesthetic effects of 2,2,2-tribromoethanol on ICR mice derived from three different sources
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Lee MR, Suh HR, Kim MW, Cho JY, Song HK, Jung YS, Hwang DY, Kim KS
- KMID: 2459305
- Lab Anim Res.
- 2018 Dec;34(4):270-278.
- doi: 10.5625/lar.2018.34.4.270
This study was conducted to compare the anesthetic effects of 2,2,2-tribromoethanol (TBE, Avertin®) in ICR mice obtained from three different sources. TBE (2.5%) was intraperitoneally injected at three doses: high-dose... -
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- Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice
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Lee K, Ko HW
- KMID: 2459296
- Lab Anim Res.
- 2018 Dec;34(4):203-210.
- doi: 10.5625/lar.2018.34.4.203
Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple... -
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- The role of hepatic macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
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Cha JY, Kim DH, Chun KH
- KMID: 2459288
- Lab Anim Res.
- 2018 Dec;34(4):133-139.
- doi: 10.5625/lar.2018.34.4.133
Nonalcoholic steatohepatitis (NASH) is becoming common chronic liver disease because of the increasing global prevalence of obesity and consequently Nonalcoholic fatty liver disease (NAFLD). However, the mechanism for progression of... -
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- Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
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Kim H, Fang S
- KMID: 2459289
- Lab Anim Res.
- 2018 Dec;34(4):140-146.
- doi: 10.5625/lar.2018.34.4.140
Though bile acids have been well known as digestive juice, recent studies have demonstrated that bile acids bind to their endogenous receptors, including Farnesoid X receptor (FXR) and G protein-coupled... -
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- Induction of superovulation in mature mice and rats using serum of spayed female dogs
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Nooranizadeh M, Mogheiseh , Kafi M, Sepehrimanesh M, Vaseghi H
- KMID: 2459297
- Lab Anim Res.
- 2018 Dec;34(4):211-215.
- doi: 10.5625/lar.2018.34.4.211
The following experiments were designed to examine the effect of serum of spayed dogs on superovulation response in mice and rats. In Experiment 1, female mice at diestrus (n=30) were... -
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- Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks
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Yoon WB, Choi HJ, Kim JE, Park JW, Kang MJ, Bae SJ, Lee YJ, Choi YS, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK
- KMID: 2459311
- Lab Anim Res.
- 2018 Dec;34(4):317-328.
- doi: 10.5625/lar.2018.34.4.317
Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced cognitive... -
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