Lab Anim Res.  2018 Dec;34(4):216-222. 10.5625/lar.2018.34.4.216.

In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7

Affiliations
  • 1Division of Gastroenterology, Vievisnamuh Hospital, Seoul, Korea.
  • 2Center for Animal Resource Development, Wonkwang University, Iksan, Korea. kimoj@wku.ac.kr
  • 3R & BD Center, Korea Yakult Co., Ltd., Yongin, Korea.
  • 4Department of Companion Animal and Animal Resources Science, Joongbu University, Geumsan-gun, Korea.

Abstract

The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of Lactobacilllus paracasei (L. paracasei) HP7, isolated from kimchi, to inhibit H. pylori growth. The effects of L. paracasei HP7 on H. pylori adhesion and H. pylori-induced inflammation were examined in AGS human gastric adenocarcinoma epithelial cells and a mouse model of H. pylori SS1 infection. L. paracasei HP7 reduced H. pylori adhesion to AGS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. H. pylori colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with L. paracasei HP7. Additionally, L. paracasei HP7 decreased gastric inflammation and epithelial lesions in the stomach of H. pylori-infected mice. These results demonstrate that L. paracasei HP7 treatment can inhibit H. pylori growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by H. pylori infection.

Keyword

Lactobacilllus paracasei; HP7; Helicobacter pylori; AGS cells; Kimchi

MeSH Terms

Adenocarcinoma
Animals
Colon
Epithelial Cells
Gastritis
Helicobacter pylori*
Helicobacter*
Humans
In Vitro Techniques*
Inflammation
Interleukin-8
Mice
Stomach
Urease
Interleukin-8
Urease
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