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Frozen-thawed gelatin-induced osteogenic cell sheets of canine adipose-derived mesenchymal stromal cells improved fracture healing in canine model

Yoon Y, Jung T, Afan Shahid M, Khan IU, Kim WH, Kweon OK

We assessed the efficacy of frozen-thawed gelatin-induced osteogenic cell sheet (FT-GCS) compared to that of fresh gelatin-induced osteogenic cell sheet (F-GCS) with adipose-derived mesenchymal stromal cells (Ad-MSCs) used as the...
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Different Bone Healing Effects of Undifferentiated and Osteogenic Differentiated Mesenchymal Stromal Cell Sheets in Canine Radial Fracture Model

Yoon Y, Khan IU, Choi KU, Jung T, Jo K, Lee SH, Kim WH, Kim DY, Kweon OK

Cell sheets technology is being available for fracture healing. This study was performed to clarify bone healing mechanism of undifferentiated (UCS) and osteogenic (OCS) differentiated mesenchymal stromal cell (MSC) sheets...
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Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle

Song J, Kim Y, Kweon OK, Kang BJ

A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact...
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Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury

Lee SH, Kim Y, Rhew D, Kim A, Jo KR, Yoon Y, Choi KU, Jung T, Kim WH, Kweon OK

Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that modulates the immune response and oxidative stress associated with spinal cord injury (SCI). This study aimed to investigate neuronal regeneration via transplantation...
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Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs

Kim Y, Lee SH, Kim WH, Kweon OK

Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem...
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Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model

Yoon D, Kang BJ, Kim Y, Lee SH, Rhew D, Kim WH, Kweon OK

Composite biological and synthetic grafts with progenitor cells offer an alternative approach to auto- or allografts for fracture repair. This study was conducted to evaluate osteogenesis of autologous serum-derived albumin...
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Identification of differentially expressed genes in gauze-exposed omentum of dogs using differential display RT-PCR

Rahman MM, Kim Y, Byeon YE, Ryu HH, Kim WH, Rayhan MU, Kweon OK

Molecular mechanisms governing peritonitis caused by the presence of aseptic gauze have remained unclear. To identify the genes involved, sterile gauze-exposed omentum was collected at 0, 6, 12, 24, and...
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Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton's jelly for treating bone defects

Kang BJ, Ryu HH, Park SS, Koyama Y, Kikuchi M, Woo HM, Kim WH, Kweon OK

Alternative sources of mesenchymal stem cells (MSCs) for replacing bone marrow (BM) have been extensively investigated in the field of bone tissue engineering. The purpose of this study was to...
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Genetic Polymorphism of Jeju Horses by Microsatellite DNA Markers in Korea

Lee JE, Shin JH, Yun YM, Lee KK, Lee H, Kweon OK, Yun YS, Suh JG, Shin NS, Seong JK

  • KMID: 2312069
  • Lab Anim Res.
  • 2010 Jun;26(2):219-221.
We determined the genetic diversity and distance between Jeju and Thoroughbred horses by genotyping for 20 microsatellite loci consisting of (TG)n repetitive sequence. The expected heterozygosity ranged from 0.1 to...
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Assessment of experimental saccular aneurysm using selective angiography in common carotid artery of rabbits

Chang DW, Kim BK, Shin JH, Yoon YM, Oh SH, Yoon YS, Hong SH, Lee KC, Lee YW, Seo KM, Kweon OK, Yoon JH, Shin NS, Lee KH, Suh JG, Seong JK

In order to study the treatment of aneurysms, the technique of making experimental aneurysms in laboratory animals must be established. In our study, to examine the feasibility of making experimental...
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Computed tomographic characteristics of acute thoracolumbar intervertebral disc disease in dogs

Lim C, Kweon OK, Choi MC, Choi J, Yoon J

Forty canine patients with a presumptive diagnosis of the intervertebral disc herniation at the thoracolumbar region were imaged. A neurological examination was performed and all patients were classified under four...
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Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury

Ryu HH, Lim JH, Byeon YE, Park JR, Seo MS, Lee YW, Kim WH, Kang KS, Kweon OK

In this study, we evaluated if the implantation of allogenic adipose-derived stem cells (ASCs) improved neurological function in a canine spinal cord injury model. Eleven adult dogs were assigned to...
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Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs

Jang BJ, Byeon YE, Lim JH, Ryu HH, Kim WH, Koyama Y, Kikuchi M, Kang KS, Kweon OK

This study was performed to evaluate the osteogenic effect of allogenic canine umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) mixed with beta-tricalcium phosphate (beta-TCP) in orthotopic implantation. Seven hundred milligrams of...
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Cerebellar vermian hypoplasia in a Cocker Spaniel

Lim JH, Kim DY, Yoon JH, Kim WH, Kweon OK

An eight-week-old female Cocker Spaniel was presented with ataxia, dysmetria and intention tremor. At 16 weeks, the clinical signs did not progress. Investigation including imaging studies of the skull and cerebrospinal...
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Erratum: Establishment of a canine spinal cord injury model induced by epidural balloon compression

Lim JH, Jung CS, Byeon YE, Kim WH, Yoon JH, Kang KS, Kweon OK

The 150 microl and 50 micol was reversed in the labeled line of the insert box in above article, on page 92, Fig. 4. The correct figure is printed below....
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Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs

Lim JH, Byeon YE, Ryu HH, Jeong YH, Lee YW, Kim WH, Kang KS, Kweon OK

This study was to determine the effects of allogenicumbilical cord blood (UCB)-derived mesenchymal stemcells (MSCs) and recombinant methionyl humangranulocyte colony-stimulating factor (rmhGCSF) on acanine spinal cord injury model after balloon...
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Establishment of a canine spinal cord injury model induced by epidural balloon compression

Lim JH, Jung CS, Byeon YE, Kim WH, Yoon JH, Kang KS, Kweon OK

A model that provides reproducible, submaximal yet sufficient spinal cord injury is needed to allow experiments leading to development of therapeutic techniques and prediction of clinical outcome to be conducted....
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Guided bone regeneration with beta-tricalcium phosphate and poly Llactide-co-glycolide-co-epsilon-caprolactone membrane in partial defects of canine humerus

Oh T, Rahman MM, Lim JH, Park MS, Kim DY, Yoon JH, Kim WH, Kikuchi M, Tanaka J, Koyama Y, Kweon OK

This study was performed to evaluate the effect of betatricalcium phosphate and poly L-lactide-co-glycolide-coepsilon- caprolactone (TCP/PLGC) membrane in the repair of partial bone defects in canine proximal humerus. Three adult...
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Mutation and overexpression of p53 as a prognostic factor in canine mammary tumors

Lee CH, Kim WH, Lim JH, Kang MS, Kim DY, Kweon OK

  • KMID: 1094689
  • J Vet Sci.
  • 2004 Mar;5(1):63-69.
We concentrated ourselves to evaluate the prognostic significance of the p53 gene mutations, its protein expression and MIB-1 index as a proliferative marker in canine mammary tumors. In the present...
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Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors

Lee CH, Kweon OK

  • KMID: 1097349
  • J Vet Sci.
  • 2002 Dec;3(4):321-325.
Mutation of the p53 tumor suppressor gene has been related in the pathogenesis of numerous human and canine cancers, including breast cancers and mammary tumors. We have investigated exons 5-8...
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