J Vet Sci.  2016 Mar;17(1):123-126. 10.4142/jvs.2016.17.1.123.

Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs

• Kim Y
• Lee SH
• Kim WH
• Kweon OK

• KMID: 2363345
• DOI: http://doi.org/10.4142/jvs.2016.17.1.123

Abstract

Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.

Keyword

adipose derived mesenchymal stem cells; decompression surgery; dog; intervertebral disc disease

MeSH Terms

Acute Disease
Adipose Tissue/cytology
Animals
Decompression, Surgical/veterinary
Dog Diseases/*therapy
Dogs
Female
Intervertebral Disc Degeneration/therapy/*veterinary
Intervertebral Disc Displacement/therapy/*veterinary
Male
Mesenchymal Stem Cell Transplantation/*veterinary
Pain Perception
Treatment Outcome

Figure

• 

  Fig. 1 Transverse T2-weighted magnetic resonance image (A) and transverse computed tomograph image (B) of dogs with intervertebral disc disease. Extruded disc materials (white arrow in A, black arrow in B) compressed the spinal cord.

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  Fig. 2 Days (mean ± SD) recovered to each grade in 34 dogs with acute intervertebral disc disease and absence of deep pain perception. n, number of recovered cases; DSX, decompression surgery alone; AD-MSCs, combination of decompression surgery and the transplantation of adipose derived mesenchymal stem cells.

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