Korean Circ J.  2020 Jan;50(1):12-21. 10.4070/kcj.2019.0288.

Therapeutic Angiogenesis with Somatic Stem Cell Transplantation

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. murohara@med.nagoya-u.ac.jp


Therapeutic angiogenesis is an important strategy to rescue ischemic tissues in patients with critical limb ischemia having no other treatment option such as endovascular angioplasty or bypass surgery. Studies indicated so far possibilities of therapeutic angiogenesis using autologous bone marrow mononuclear cells, CD34⁺ cells, peripheral blood mononuclear cells, adipose-derived stem/progenitor cells, and etc. Recent studies indicated that subcutaneous adipose tissue contains stem/progenitor cells that can give rise to several mesenchymal lineage cells. Moreover, these mesenchymal progenitor cells release a variety of angiogenic growth factors including vascular endothelial growth factor, fibroblast growth factor, hepatocyte growth factor and chemokine stromal cell-derived factor-1. Subcutaneous adipose tissues can be harvested by less invasive technique. These biological properties of adipose-derived regenerative cells (ADRCs) implicate that autologous subcutaneous adipose tissue would be a useful cell source for therapeutic angiogenesis in humans. In this review, I would like to discuss biological properties and future perspective of ADRCs-mediated therapeutic angiogenesis.


Angiogenesis; Adipose-derived regenerative cell; Therapeutic angiogenesis; Mesenchymal stem cell; Ischemia

MeSH Terms

Bone Marrow
Fibroblast Growth Factors
Hepatocyte Growth Factor
Intercellular Signaling Peptides and Proteins
Mesenchymal Stromal Cells
Stem Cell Transplantation*
Stem Cells*
Subcutaneous Fat
Vascular Endothelial Growth Factor A
Fibroblast Growth Factors
Hepatocyte Growth Factor
Intercellular Signaling Peptides and Proteins
Vascular Endothelial Growth Factor A
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