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Fat Graft with Allograft Adipose Matrix and Magnesium Hydroxide-Incorporated PLGA Microspheres for Effective Soft Tissue Reconstruction

Kim DH, Kim DS, Ha HJ, Jung JW, Baek SW, Baek SH, Kim TH, Lee JC, Hwang E, Han DK

BACKGROUND: Autologous fat grafting is one of the most common procedures used in plastic surgery to correct soft tissue deficiency or depression deformity. However, its clinical outcomes are often suboptimal,...
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68 Ga-DOTA-RGD 2 Uptake in Plantar Fasciitis: New Insights into its Pathogenesis

Aggarwal P, Singh H, Kumar R, Sharma A

Plantar fasciitis is chronic degenerative tendinopathy of the plantar fascia. Although it has many treatment modalities, none has been very effective due to the largely unknown pathogenesis of this condition....
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A clinical and pathological update on hepatocellular carcinoma

Renne SL, Tommaso LD

It is estimated that more than 1 million individuals will be affected annually by hepatocellular carcinoma (HCC) by 2025. HCC can be broadly grouped into two major molecular subgroups, each...
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Healthy versus Unhealthy Adipose Tissue Expansion: the Role of Exercise

Meister BM, Hong SG, Shin J, Rath M, Sayoc J, Park JY

Although the hallmark of obesity is the expansion of adipose tissue, not all adipose tissue expansion is the same. Expansion of healthy adipose tissue is accompanied by adequate capillary angiogenesis and...
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Current Knowledge and Future Therapeutic Prospects in Symptomatic Intervertebral Disc Degeneration

Kim JH, Ham CH, Kwon WK

Intervertebral disc (IVD) degeneration is the main source of intractable lower back pain, and symptomatic IVD degeneration could be due to different degeneration mechanisms. In this article, we describe the...
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A Synthetic Analog of Resveratrol Inhibits the Proangiogenic Response of Liver Sinusoidal Cells during Hepatic Metastasis

Olaso E, Benedicto A, Lopategi A, Cossio FP, Arteta B

We utilized Fas21, a resveratrol analog, to modulate the function of hepatic stellate cells (HSCs) and liver sinusoidal endothelial cells (LSECs) during the angiogenic phase of murine liver metastasis by...
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Effects of Particulate Matter on Wound Healing: An In Vivo Study

Lee HM, Kim CS, Na YC, Yoon CS, Kim JH, Yun SS, Park JH

Background: Particulate matter (PM) is known to increase the risk of diseases in major organs and PM may also slow the complex process of wound healing. We investigated the effect...
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Enhancing the Angiogenic and Proliferative Capacity of Dermal Fibroblasts with Mulberry ( Morus alba. L) Root Extract

Im J, Hyun J, Kim SW, Bhang SH

BACKGROUND: Enhancing blood flow and cell proliferation in the hair dermis is critical for treating hair loss. This study was designed to aid the development of alternative and effective solutions...
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Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice

Später T, Marschall JE, Brücker LK, Nickels RM, Metzger W, Menger MD, Laschke MW

BACKGROUND: Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental studies in rodents exclusively use epididymal adipose tissue as a visceral fat source for MVF...
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Comparative Pre-clinical Efficacy of Chinese and Indian Cultivars of Bitter Melon (Momordica charantia) against Pancreatic Cancer

Kandhari K, Paudel S, Raina K, Agarwal C, Kant R, Wempe MF, Bryant CO, Agarwal R

Given the high rates of incidence and mortality associated with pancreatic cancer (PanC), there is a need to develop alternative strategies to target PanC. Recent studies have demonstrated that fruits...
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Non-thrombotic ischemic cerebrovascular events related to the use of tyrosine kinase inhibitors in patients with cancer: high-resolution magnetic resonance imaging findings

Sim JE, Park J, Bang OY

The targeted cancer therapies that have been introduced in recent years are directed against cancer-specific molecules and signaling pathways, and thus, they have limited nonspecific toxicities. However, major vascular events,...
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Irisin Enhances Angiogenesis of Mesenchymal Stem Cells to Promote Cardiac Function in Myocardial Infarction via PI3k/Akt Activation

Yang F, Wang Z, Li B, He Y, Du F, Tian S, Zhang Y, Yang Y

Background and Objectives: With the growing incidence of acute myocardial infarction (MI), angiogenesis is vital for cardiac function post-MI. The role of bone marrow mesenchymal stem cells (BMSCs) in angiogenesis...
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Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight

Ghollasi M, Ghasembaglou S, Rahban D, Korani M, Motallebnezhad M, Asadi M, Zarredar H, Salimi A

The interactions between the tumor microenvironment and the tumor cells confers a condition that accelerate or decelerate the development of tumor. Of these cells, mesenchymal stem cells (MSCs) have the...
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ER71/ETV2 Promotes Hair Regeneration from Chemotherapeutic Drug-Induced Hair Loss by Enhancing Angiogenesis

Lee TJ, Kang HK, Berry JC, Joo HG, Park C, Miller MJ, Choi K

Chemotherapy-induced alopecia and hair loss can be stressful in patients with cancer. The hair grows back, but sometimes the hair tends to stay thin. Therefore, understanding mechanisms regulating hair regeneration...
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Mesenchymal Stem Cell Transplantation for Ischemic Diseases: Mechanisms and Challenges

Van Nguyen TT, Vu NB, Pham PV

Ischemic diseases are conditions associated with the restriction or blockage of blood supply to specific tissues. These conditions can cause moderate to severe complications in patients, and can lead to...
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Current Understanding and Future Perspectives of Interstitial Cystitis/Bladder Pain Syndrome

Ueda T, Hanno PM, Saito R, Meijlink JM, Yoshimura N

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic disease characterized by suprapubic pain and lower urinary tract symptoms. Perhaps because of the heterogeneous nature of this disease and its multifactorial...
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Experimental Tracheal Replacement: Angiogenesis and Null Apoptosis Promote Stenosis

Santibáñez-Salgado JA, Sotres-Vega A, Gaxiola-Gaxiola MO, Villalba-Caloca J, Lozoya KB, Zúñiga-Ramos JA

Background: Tracheal replacement is a challenge for thoracic surgeons due to stenosis in the trachea-prosthesis anastomosis. We propose that stenosis occurs due to fibrosis as a result of an abnormal...
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Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity

Kim JY, Rhim WK, Seo HJ, Lee JY, Park CG, Han DK

BACKGROUND: In order to produce and isolate the exosome derived from the cell of interests, a serum free environment (starvation) has been essential for excluding the unknown effect from serum-derived...
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Angiogenesis-Targeted 68Ga-DOTA-RGD 2 PET/CT Imaging: a Potential Theranostic Application in the Case of Chondrosarcoma

Krishnaraju VS, Kumar R, Sood A, Shukla J, Subramanian K, Kakkar N, Panda N, Mittal BR

Chondrosarcoma is a cartilaginous tumor of mesenchymal origin. The histology and grade of the tumor determine the chances of relapse and survival. These tumors usually respond poorly to chemo-radiotherapy in...
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Enhancement of Wound Healing by Conditioned Medium of Adipose-Derived Stromal Cell with Photobiomodulation in Skin Wound

Park IS

Background and Objectives: The objective of this study was to investigate whether conditioned medium from photobiomodulation (PBM) irradiated adipose-derived stromal cell (ASC) spheroids prior to implanting could stimulate angiogenesis and...
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