J Vet Sci.  2017 Dec;18(4):555-558. 10.4142/jvs.2017.18.4.555.

Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle

• Song J
• Kim Y
• Kweon OK
• Kang BJ

• KMID: 2398517
• DOI: http://doi.org/10.4142/jvs.2017.18.4.555

Abstract

A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.

Keyword

adipose-derived mesenchymal stromal cells; bone morphogenetic protein 7; dogs; ununited fractures

MeSH Terms

Animals
Bone Morphogenetic Protein 7
Bone Regeneration
Child
Dogs
Fractures, Ununited
Gangwon-do
Hospitals, Animal
Humans
Play and Playthings*
Radius
Ulna
Bone Morphogenetic Protein 7

Figure

• 

  Fig. 1 Radiographic images acquired 1 month (A), 4 months (B), and 5 months (C) after surgery with external skeletal fixation.

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  Fig. 2 Postoperative radiography shows the absence of the fracture line at 9 weeks after surgical application of a locking plate and screws and Ad-MSC sheets overexpressing BMP-7. Radiographic images acquired 2 weeks (A), 4 weeks (B), 7 weeks (C), 9 weeks (D), and 16 weeks after surgery (E).

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