- Therapeutic Aspects of Mesenchymal Stem Cell-Based Cell Therapy with a Focus on Human Amniotic Epithelial Cells in Multiple Sclerosis: A Mechanistic Review
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ArefNezhad R, Motedayyen H, Mohammadi A
- KMID: 2519367
- Int J Stem Cells.
- 2021 Aug;14(3):241-251.
- doi: 10.15283/ijsc21032
Multiple sclerosis (MS) is an inflammatory disease of central nervous system (CNS). The mmune system plays an important role in its pathogenesis. Current treatments are unable to cure patients and... -
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- Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Therapy, Preclinical and Clinical Evidence
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Kiaie N, Mousavi Ghanavati SP, Miremadi SS, Hadipour A, Aghdam RM
- KMID: 2519368
- Int J Stem Cells.
- 2021 Aug;14(3):252-261.
- doi: 10.15283/ijsc20182
Since the emergence of the novel coronavirus, named COVID-19, researchers are looking for a treatment to stop the devastating pandemic. During these efforts, mesenchymal stem cells (MSCs), the potential next... -
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- Umbilical Cord Mesenchymal Stem Cells for Inhibiting the Fibrosis and Autoimmune Development in HOCl-Induced Systemic Scleroderma Mouse Model
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Jin X, Hou J, Zheng K, Wei D, Zhang A, Wang S, Mei H, Li C, Cheng L, Sun X
- KMID: 2519369
- Int J Stem Cells.
- 2021 Aug;14(3):262-274.
- doi: 10.15283/ijsc20002
Background and Objectives: Systemic scleroderma (SSc) is a rare and serious connective tissue disease, an autoimmune disease, and a rare refractory disease. In this study, preventive effect of single systemic... -
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- Role of miRNA-324-5p-Modified Adipose-Derived Stem Cells in Post-Myocardial Infarction Repair
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Ji Z, Wang C, Tong Q
- KMID: 2519372
- Int J Stem Cells.
- 2021 Aug;14(3):298-309.
- doi: 10.15283/ijsc21025
Background and Objectives: To seek out the role of mircoRNA (miR)-324-5p-modified adipose-derived stem cells (ADSCs) in post-myocardial infarction (MI) myocardial repair. Methods and Results: Rat ADSCs were cultivated and then identified... -
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- PSC-MSC-Derived Exosomes Protect against Kidney Fibrosis In Vivo and In Vitro through the SIRT6/β-Catenin Signaling Pathway
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Liu L, Wu Y, Wang P, Shi M, Wang J, Ma H, Sun D
- KMID: 2519373
- Int J Stem Cells.
- 2021 Aug;14(3):310-319.
- doi: 10.15283/ijsc20184
Background and Objectives: Chronic kidney disease (CKD) has a major impact on the quality of life of patients, and renal fibrosis is a critical pathological change in the disease. It... -
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- Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Regulate Macrophage Polarization to Attenuate Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage in Mice
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Chen X, Wei Q, Sun H, Zhang X, Yang C, Tao Y, Nong G
- KMID: 2519375
- Int J Stem Cells.
- 2021 Aug;14(3):331-340.
- doi: 10.15283/ijsc20156
Background and Objectives: To investigate the effect and the underlying mechanism of exosomes secreted by human umbilical cord mesenchymal stem cells (hUCMSCs) on diffuse alveolar hemorrhage (DAH) in murine lupus. Methods... -
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- The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
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Liu B, Gan W, Jin Z, Wang M, Cui G, Zhang H, Wang H
- KMID: 2519371
- Int J Stem Cells.
- 2021 Aug;14(3):286-297.
- doi: 10.15283/ijsc20188
Background and Objectives: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a critical role in the success of lumbar spinal fusion with autogenous bone graft. This study aims... -
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- Galectin-3 Derived from HucMSC Exosomes Promoted Myocardial Fibroblast-to-Myofibroblast Differentiation Associated with β-catenin Upregulation
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Guo Q, Zhao Y, Li J, Huang C, Wang H, Zhao X, Wang M, Zhu W
- KMID: 2519374
- Int J Stem Cells.
- 2021 Aug;14(3):320-330.
- doi: 10.15283/ijsc20186
Background and Objectives: Galectin-3 promotes fibroblast-to-myofibroblast differentiation and facilitates injury repair. Previous studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) promote the differentiation of... -
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- Bie Jia Jian Pill Combined with Bone Mesenchymal Stem Cells Regulates microRNA-140 to Suppress Hepatocellular Carcinoma Stem Cells
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Jingjing H, Hongna H, Wenfu Z, Jianlin L, Guochu H, Yuanjia L, Songlin C, Yueqiang H
- KMID: 2519370
- Int J Stem Cells.
- 2021 Aug;14(3):275-285.
- doi: 10.15283/ijsc20157
Background and Objectives: Cancer stem cells (CSCs) with tumorigenic potential are reported as the crucial factors of hepatocellular carcinoma (HCC) recurrence and therapy resistance. Bone mesenchymal stem cells (BMSCs) are... -
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- MiR-181a Promotes Spermatogenesis by Targeting the S6K1 Pathway
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Wang L, Sun J, Han J, Ma Z, Pan M, Du Z
- KMID: 2519376
- Int J Stem Cells.
- 2021 Aug;14(3):341-350.
- doi: 10.15283/ijsc21001
Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured... -
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