- Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
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Moon IS, Lee HJ, Park IS
- KMID: 1778833
- J Korean Med Sci.
- 2012 Oct;27(10):1241-1247.
- doi: 10.3346/jkms.2012.27.10.1241
Long-term synaptic plasticity requires addition of new proteins at the synaptic site. The local protein synthesis at subsynaptic sites confers advantageous mechanisms that would regulate the protein composition in local... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb
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Yun UJ, Park SE, Shin DY
- KMID: 1015457
- Exp Mol Med.
- 2011 Jul;43(7):389-392.
- doi: 10.3858/emm.2011.43.7.042
Cellular senescence is a tumor-suppressive process instigated by proliferation in the absence of telomere replication, by cellular stresses such as oncogene activation, or by activation of the tumor suppressor proteins,... -
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- The Role of Foxo3 in Leydig Cells
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Choi YS, Song JE, Kong BS, Hong JW, Novelli S, Lee EJ
- KMID: 2345887
- Yonsei Med J.
- 2015 Nov;56(6):1590-1596.
- doi: 10.3349/ymj.2015.56.6.1590
PURPOSE: Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3... -
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- Expression of Beta-catenin and E-cadherin in Early Gastric Cancer: Correlation with Clinicopathologic Parameters
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Song BJ, Park YJ, Kim HS, Kim CN, Chang SH
- KMID: 772610
- Korean J Gastroenterol.
- 2004 Feb;43(2):82-89.
BACKGROUND/AIMS: Beta-catenin is known to perform two unrelated functions in cadherin-mediated cell to cell adhesion system and Wnt pathway. Recent studies reported cytoplasmic and nuclear accumulation of beta-catenin by... -
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- C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro
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Kim JW, Ahn YH
- KMID: 755211
- Exp Mol Med.
- 2002 Nov;34(5):379-384.
The expression of the GLUT2 glucose transporter gene in liver is suppressed in cultured hepatoma cell lines and primary cultured hepatocytes. Earlier report showed that CCAAT/enhancer binding protein (C/EBP) regulates... -
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- HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene
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Cha JY, Kim HI, Im SS, Li TZ, Ahn YH
- KMID: 1085740
- Exp Mol Med.
- 2001 Jun;33(2):59-63.
A possible role of hepatocyte nuclear factor 1 (HNF1) or HNF3, a predominant trans-acting factors of hepatic or pancreatic beta-cells, was examined on the tissue specific interdependent expression of glucokinase... -
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- Coptidis rhizoma extract protects against cytokine-induced death of pancreatic beta-cells through suppression of NF-kappa B activation
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Kim EK, Kwon KB, Han MJ, Song MY, Lee JH, Lv N, Ka SO, Yeom SR, Kwon YD, Ryu DG, Kim KS, Park JW, Park R, Park BH
- KMID: 1094655
- Exp Mol Med.
- 2007 Apr;39(2):149-159.
We demonstrated previously that Coptidis rhizoma extract (CRE) prevented S-nitroso-N-acetylpenicillamine-induced apoptotic cell death via the inhibition of mitochondrial membrane potential disruption and cytochrome c release in RINm5F (RIN) rat insulinoma... -
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- Akt is involved in the inhibition of cell proliferation by EGF
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Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY
- KMID: 756072
- Exp Mol Med.
- 2007 Aug;39(4):491-498.
Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways... -
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- The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation
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Park BH, Park JW
- KMID: 1085741
- Exp Mol Med.
- 2001 Jun;33(2):64-68.
This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
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Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT
- KMID: 1047077
- Exp Mol Med.
- 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is... -
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- Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer
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Lee SS, Cho KJ, Hong SI, Myoung NK, Jang JJ
- KMID: 1064962
- J Korean Med Sci.
- 1998 Apr;13(2):153-158.
- doi: 10.3346/jkms.1998.13.2.153
We unexpectedly observed strong nuclear overexpression of bcl-2 protein in advanced stomach cancer. As far as we know, such expression has not yet been reported. To investigate the significance... -
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- Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase
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Ha TS, Park HY, Seong SB, Ahn HY
- KMID: 2363691
- J Korean Med Sci.
- 2016 Apr;31(4):535-541.
- doi: 10.3346/jkms.2016.31.4.535
Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the... -
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- Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
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Jang IS, Park MY, Shin IW, Sohn JT, Lee HK, Chung YK
- KMID: 1779628
- Yonsei Med J.
- 2010 Nov;51(6):838-844.
- doi: 10.3349/ymj.2010.51.6.838
PURPOSE: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after... -
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- Acute Upper Gastrointestinal Bleeding Due to Metastatic Lung Cancer: An Unusual Case
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Altintas E, Sezgin O, Uyar B, Polat A
- KMID: 1110755
- Yonsei Med J.
- 2006 Apr;47(2):276-277.
- doi: 10.3349/ymj.2006.47.2.276
There have been several published reports on metastatic lesions in the stomach, but the number of cases have been limited due to the low frequency of the condition. Metastatic lesions... -
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- Heterogeneity of Invasive Ductal Carcinoma: Proposal for a Hypothetical Classification
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Jo BH, Chun YK
- KMID: 1778429
- J Korean Med Sci.
- 2006 Jun;21(3):460-468.
- doi: 10.3346/jkms.2006.21.3.460
To investigate what heterogeneity exists in breast cancer, 228 consecutive patients with operable invasive duetal carcinoma (IDC), not otherwise specified, were categorized on the basis of the horizontal progression model... -
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- Epstein-Barr Virus, Beta-Catenin, and E-cadherin in Gastric Carcinomas
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Jung IM, Chung JK, Kim YA, Kim JE, Heo SC, Ahn YJ, Hwang KT, Kim BG, Lee KL, Kim CW, Kim WH, Chang MS
- KMID: 1713293
- J Korean Med Sci.
- 2007 Oct;22(5):855-861.
- doi: 10.3346/jkms.2007.22.5.855
Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin... -
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- Cadmium Induced Acute Lung Injury and TUNEL Expression of Apoptosis in Respiratory Cells
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Kwon KY, Jang JH, Kwon SY, Cho CH, Oh HK, Kim SP
- KMID: 1130034
- J Korean Med Sci.
- 2003 Oct;18(5):655-662.
- doi: 10.3346/jkms.2003.18.5.655
We examined the ultrastructural features of the lung parenchyma and the expression of apoptosis of the respiratory cells by TUNEL technique. Male Sprague-Dawley rats (n=30) were intra-tracheally injected with cadmium... -
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- NF-kappaB Binding Activity and Cyclooxygenase-2 Expression in Persistent betaCCI(4)-Treated Rat Liver Injury
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Kim SH, Chu HJ, Kang DH, Song GA, Cho M, Yang US, Kim HJ, Chung HY
- KMID: 648675
- J Korean Med Sci.
- 2002 Apr;17(2):193-200.
- doi: 10.3346/jkms.2002.17.2.193
The involvement of NF-kappaB binding activity is known to be important in the mechanism of acute liver injury and in the induction of cyclooxygenase (COX-2). This study was performed to... -
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