Exp Mol Med.  2001 Jun;33(2):64-68.

The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation

• Park BH
• Park JW

Abstract

This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum prevented alloxan-induced hyperglycemia and hypoinsulinemia in a dose dependent manner. Histological examination of pancreatic tissue from A. xanthoides extract treated mice showed that the islet cells remain unaffected by alloxan treatment. NFkappaB activation in the pancreas 30 min after alloxan injection (60 mg/kg, iv), as assessed by an electrophoretic mobility shift assay, was not detected in the mice pretreated with A. xanthoides extract. These results suggest that NFkappaB activation may be one of the critical determinant in the progression of the disease. Considering the preventive effect of A. xanthoides extract from alloxan-induced diabetics development, these results may provide the possible therapeutic value of A. xanthoides extract for the prevention of diabetes mellitus progression.

Keyword

Amomum xanthoides; alloxan; NFkB; diabetes

MeSH Terms

Alloxan/*pharmacology
Animal
Blood Glucose/metabolism
Cell Nucleus/metabolism
Diabetes Mellitus, Experimental/*prevention & control
Dose-Response Relationship, Drug
Female
Hyperglycemia/prevention & control
Islets of Langerhans/metabolism
Mice
Mice, Inbred ICR
NF-kappa B/*antagonists & inhibitors
Pancreas/metabolism
Plant Extracts/*therapeutic use
Time Factors