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Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice

Park MK, Kim DK, Lee HJ

  • KMID: 1119330
  • Exp Mol Med.
  • 2003 Dec;35(6):494-500.
Hepatocyte growth factor (HGF) is a potent mitogen and promoter of proliferation of insulin producing beta cells of pancreatic islets. To study the role of HGF, an adenoviral vector carrying...
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A mechanism of differential expression of GLUT2 in hepatocyte and pancreatic beta-cell line

Kim JW, Kim YK, Ahn YH

  • KMID: 754982
  • Exp Mol Med.
  • 1998 Mar;30(1):15-20.
DNase I footprinting assay using liver nuclear extracts revealed six protected regions between nucleotide -600 and +110 and hence named Box I-VI. Upstream promoter element (UPE), a DNA element playing crucial role...
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Reduced dihydroxyacetone sensitivity and normal sensitivity to glyceraldehyde and oxidizing agent of ATP-sensitive K+ channels of pancreatic beta cells in NIDDM rats

Song DK, Park WK, Bae JH, Park MK, Kim SJ, Ho WK, Earm YE

The inhibition of ATP-sensitive K+(KATP) channels in pancreatic beta cells is a key step of insulin secretion induced by glucose. Glucose-induced insulin secretion from the beta cells is selectively...
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The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation

Park BH, Park JW

  • KMID: 1085741
  • Exp Mol Med.
  • 2001 Jun;33(2):64-68.
This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum...
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A Case of Alpha-cell Nesidioblastosis and Hyperplasia with Multiple Glucagon-producing Endocrine Cell Tumor of the Pancreas

Kang H, Kim S, Lim TS, Lee HW, Choi H, Kang CM, Kim HG, Bang S

Nesidioblastosis is a term used to describe pathologic overgrowth of pancreatic islet cells. It also means maldistribution of islet cells within the ductules of exocrine pancreas. Generally, nesidioblastosis occurs in...
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