- A Review of Modeling Approaches to Predict Drug Response in Clinical Oncology
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Park K
- KMID: 2374182
- Yonsei Med J.
- 2017 Jan;58(1):1-8.
- doi: 10.3349/ymj.2017.58.1.1
Model-based approaches have emerged as important tools for quantitatively understanding temporal relationships between drug dose, concentration, and effect over the course of treatment, and have now become central to optimal... -
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- Pharmacodynamic principles and the time course of delayed and cumulative drug effects
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Holford N
- KMID: 2413827
- Transl Clin Pharmacol.
- 2018 Jun;26(2):56-59.
- doi: 10.12793/tcp.2018.26.2.56
This tutorial reviews the principles of the concentration — effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining... -
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- Overview of Therapeutic Drug Monitoring
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Kang JS, Lee MH
- KMID: 1785634
- Korean J Intern Med.
- 2009 Mar;24(1):1-10.
- doi: 10.3904/kjim.2009.24.1.1
Therapeutic drug monitoring (TDM) is the clinical practice of measuring specific drugs at designated intervals to maintain a constant concentration in a patient's bloodstream, thereby optimizing individual dosage regimens. It... -
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- Resolution of experimental intravitreal fibrin by tissue plasminogen activator
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Min WK, Kim YB
- KMID: 1735063
- Korean J Ophthalmol.
- 1990 Dec;4(2):58-65.
- doi: 10.3341/kjo.1990.4.2.58
Intravitreal fibrin clots were produced by intravitreal injection of 0.2 ml of autologous plasma in 62 rabbit eyes. The intravitreal injection of 0.25 micrograms or more of tissue plasminogen activator(tPA)... -
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- Immediate Effects of Methylprednisolone Pulse Therapy on the Immune Response
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Lee SK, Hong CS
- KMID: 1729571
- Yonsei Med J.
- 1988 Dec;29(4):373-378.
- doi: 10.3349/ymj.1988.29.4.373
To study the immediate effects of high-dose intravenous methylprednisolone pulse therapy on the immune mechanisms in the absence of other immunosuppressive agents, we treated ten patients with active systemic... -
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- Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Production in Mice
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Kim JY, Chung BH
- KMID: 1099829
- J Vet Sci.
- 2003 Apr;4(1):103-108.
The dietary effect of conjugated linoleic acid (CLA) on the response of the immunoglobulin (serum and tissue) production in Balb/C mice was examined at three doses: 0 %(control), 0.5% and... -
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- Optic neuropathy associated with ethambutol in Koreans
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Choi SY, Hwang JM
- KMID: 1375112
- Korean J Ophthalmol.
- 1997 Dec;11(2):106-110.
- doi: 10.3341/kjo.1997.11.2.106
Ethambutol is a useful first line antituberculous drug, but can cause significant visual impairment. In order to determine the clinical manifestations of optic neuropathy associated with ethambutol, and the margin... -
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- Ideal concentration of growth factors in rabbit's flexor tendon culture
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Kang HJ, Kang ES
- KMID: 1099875
- Yonsei Med J.
- 1999 Feb;40(1):26-29.
- doi: 10.3349/ymj.1999.40.1.26
Growth factors have the ability to stimulate matrix synthesis and cell proliferation in rabbit flexor tendon. Maximal stimulation effects of growth factors have a wide variation. It depends... -
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- The Interaction of Gabapentin and N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on Mechanical Allodynia in Rats with a Spinal Nerve Ligation
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Park JY, Jun IG
- KMID: 1785829
- J Korean Med Sci.
- 2008 Aug;23(4):678-684.
- doi: 10.3346/jkms.2008.23.4.678
We examined the antiallodynic interaction between gabapentin and adenosine A1 receptor agonist, N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA), in a rat model of nerve ligation injury. Rats were prepared with ligation of left... -
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- Secretory response of cultured acinar cells of rat pancreas to cholecystokinin
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Kim H, Kim KH
- KMID: 1728891
- Yonsei Med J.
- 1996 Dec;37(6):405-411.
- doi: 10.3349/ymj.1996.37.6.405
To determine the adequate models for studying the functions of pancreatic acinar cells, secretory responses to CCK and to CCK receptor antagonist, L-364, 718 were examined in freshly isolated cells... -
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- Autoimmune Chronic Pancreatitis Relapsing Despite the Maintenance Dose of Steroid
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Pyun DK, Choi WB, Kim MH, Yun JP, Lee SS, Seo DW, Lee SK
- KMID: 1718040
- Korean J Intern Med.
- 2005 Jun;20(2):163-167.
- doi: 10.3904/kjim.2005.20.2.163
Autoimmune chronic pancreatitis is a disease characterized by diffuse swelling of the pancreas, irregular narrowing of the main pancreatic duct and elevated levels of serum IgG, and lymphoplasmacytic infiltration is... -
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- A Phase II Study of Vinorelbine, Mitomycin C and Cisplatin Chemotherapy for Advanced Non-Small Cell Lung Cancer
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Kwon MR, Jeong TY, Yuh YJ, Kim SR
- KMID: 759617
- Korean J Intern Med.
- 2002 Dec;17(4):240-244.
BACKGROUND: This prospective phase II trial was performed to determine the efficacy and toxicity of mitomycin C, vinorelbine and cisplatin combination chemotherapy for patients with previously untreated stage IIIB... -
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- How Should Azathioprine Be Dosed in Crohn's Disease? A Novel Strategy of Maximum Dose-titration Based on the Lower Limit of Leukocyte Count and Tolerability
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Lim CS, Moon W, Park SJ, Park MI, Choi JM, Yoo JH, Kim JB, Lee JS
- KMID: 1775748
- Korean J Gastroenterol.
- 2013 Aug;62(2):111-116.
- doi: 10.4166/kjg.2013.62.2.111
BACKGROUND/AIMS: Although general guidelines have suggested weight-based dosing of azathioprine (AZA, 2.5 mg/kg/day) for Crohn's disease (CD), a substantial number of patients develop bone marrow suppression. The aim of this... -
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- Hemodynamic Effects of Gabapentin in Rats
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Yoon MH, Choi JI
- KMID: 648896
- J Korean Med Sci.
- 2003 Aug;18(4):478-482.
- doi: 10.3346/jkms.2003.18.4.478
Gabapentin has been known to elicit the antinociceptive effect. However, little has been known about the effect of gabapentin on the cardiovascular system. The author's aim of this experiment was... -
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- Determination of Practical Dosing of Warfarin in Korean Outpatients with Mechanical Heart Valves
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Lee BK, Lee JY, Jeong YM, Lee MK, Kim KB, Ahn H
- KMID: 1915901
- Korean J Thorac Cardiovasc Surg.
- 2005 Nov;38(11):761-772.
BACKGROUND: Following the implantation of heart valve prostheses, it is important to maintain therapeutic INR to reduce the risk of thromboembolism. The objective of this study was to suggest a... -
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- Effect of DA-8159, a Selective Phosphodiesterase Type 5 Inhibitor, on Electroretinogram and Retinal Histology in Rabbits
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Cho HK, Kang KK, Ahn GJ, Shim HJ, Kim WB
- KMID: 2157690
- J Korean Med Sci.
- 2004 Aug;19(4):586-590.
- doi: 10.3346/jkms.2004.19.4.586
DA-8159, a selective inhibitor of phosphodiesterase type 5, was developed as a new drug for erectile dysfunction. The effect of DA-8159 on the electroretinogram (ERG) and the retinal histopathology were... -
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- Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats
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Yoon CY, Hong CM, Song JY, Cho YY, Choi KS, Lee BJ, Kim CK
- KMID: 1103506
- J Vet Sci.
- 2001 Apr;2(1):47-51.
The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric... -
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- A reduced dose of ribavirin does not influence the virologic response during pegylated interferon alpha-2b and ribavirin combination therapy in patients with genotype 1 chronic hepatitis C
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You BC, Kim YS, Kim HI, Kim SH, Park SS, Seo YR, Kim SG, Lee SW, Kim HS, Jeong SW, Jang JY, Kim BS
- KMID: 1392906
- Clin Mol Hepatol.
- 2012 Sep;18(3):272-278.
- doi: 10.3350/cmh.2012.18.3.272
BACKGROUND/AIMS: When combined with pegylated interferon alpha-2b (Peg-IFN alpha-2b) for the treatment of genotype 1 chronic hepatitis C (CHC) in Korea, the current guideline for the initial ribavirin (RBV) dose... -
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- Dose-Response Relationship between Alanine Aminotransferase Levels within the Reference Interval and Metabolic Syndrome in Chinese Adults
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Wu P, Chen Q, Chen L, Zhang P, Xiao J, Chen X, Liu M, Wang S
- KMID: 2374202
- Yonsei Med J.
- 2017 Jan;58(1):158-164.
- doi: 10.3349/ymj.2017.58.1.158
PURPOSE: Elevation in serum alanine aminotransferase (ALT) levels is a biomarker for metabolic syndrome (MS); however, the relationship has not been fully investigated within the reference interval of ALT levels.... -
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- Teicoplanin Dosing Strategy for Treatment of Staphylococcus aureus in Korean Patients with Neutropenic Fever
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Ahn BJ, Yim DS, Lee DG, Kwon JC, Kim SH, Choi SM
- KMID: 1727994
- Yonsei Med J.
- 2011 Jul;52(4):616-623.
- doi: 10.3349/ymj.2011.52.4.616
PURPOSE: The present study was conducted to determine and compare the target attainment rate (TAR) between microorganism-nonspecific (Ctrough) and microorganism-specific (AUC24/MIC) targets over two weeks of teicoplanin administration according to... -
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