- Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation
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Lee KY, Park JS, Jee YK, Rosen GD
- KMID: 1121100
- Exp Mol Med.
- 2002 Dec;34(6):462-468.
TNF-related apoptosis-inducing ligand (TRAIL/Apo- 2L), a newly identified member of the TNF family promotes apoptosis by binding to the transmembrane receptors (TRAIL-R1/DR4 and TRAIL-R2/ DR5). TRAIL known to activate... -
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- Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappa B pathway in human dermal fibroblasts
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Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS
- KMID: 1119320
- Exp Mol Med.
- 2009 Aug;41(8):548-554.
- doi: 10.3858/emm.2009.41.8.060
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the... -
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- NF-kappa B decoy potentiates the effects of radiation on vascular smooth muscle cells by enhancing apoptosis
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Zhang SY, Park KW, Oh S, Cho HJ, Cho HJ, Park JS, Cho YS, Koo BK, Chae IH, Choi DJ, Kim HS, Lee MM
- KMID: 1033097
- Exp Mol Med.
- 2005 Feb;37(1):18-26.
NF-kappa B promotes cell survival against external stress such as radiation. We examined whether NF-kappa B decoy transfection enhances the antiproliferative effects of radiation on vascular smooth muscle cells (VSMCs)... -
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- Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion- induced liver injury by inhibiting NF-kappa B activation
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Wang J, Qiao L, Li Y, Yang G
- KMID: 1072949
- Exp Mol Med.
- 2008 Dec;40(6):686-698.
- doi: 10.3858/emm.2008.40.6.686
Intestinal ischemia-reperfusion (I/R) is an important event in the pathogenesis of multiple organ dysfunction syndrome (MODS). The aim of this study is to determine the effects of ginsenoside Rb1 on... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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- Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
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Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ
- KMID: 1058706
- Exp Mol Med.
- 2011 Dec;43(12):684-692.
- doi: 10.3858/emm.2011.43.12.079
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads... -
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- beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macro phages by suppressing redox-based NF-kappaB activation
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Bai SK, Lee SJ, Na HJ, Ha KS, Han JA, Lee H, Kwon YG, Chung CK, Kim YM
- KMID: 1093467
- Exp Mol Med.
- 2005 Aug;37(4):323-334.
beta-Carotene has shown antioxidant and antiinflammatory activities; however, its molecular mechanism has not been clearly defined. We examined in vitro and in vivo regulatory function of beta-carotene on the production... -
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- The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation
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Park BH, Park JW
- KMID: 1085741
- Exp Mol Med.
- 2001 Jun;33(2):64-68.
This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum... -
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