Anat Cell Biol.  2019 Dec;52(4):462-468. 10.5115/acb.19.210.

Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons

Affiliations
  • 1Department of Anatomy and Neuroscience, Eulji University College of Medicine, Daejeon, Korea. rswoo@eulji.ac.kr
  • 2Department of Emergency Medical Technology, Daejeon University, Daejeon, Korea. jhlee@dju.kr

Abstract

The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to protect against focal cerebral ischemia. The aim of the present study was to investigate the neuroprotective effect of NRG1 in primary hippocampal neurons and its underlying mechanism. Our data showed oxygen-glucose deprivation (OGD)-induced cytotoxicity and overexpression of ErbB4 in primary hippocampal neurons. Moreover, pretreatment with NRG1 could inhibit OGD-induced overexpression of ErbB4. In addition, NRG1 significantly attenuated neuronal death induced by OGD. The neuroprotective effect of NRG1 was blocked in ischemic neurons after pretreatment with AG1478, an inhibitor of ErbB4, but not after pretreatment with AG879, an inhibitor of ErbB2. These results indicate an important role of ErbB4 in NRG1-mediated neuroprotection, suggesting that endogenous ErbB4 might serve as a valuable therapeutic target for treating global cerebral ischemia.

Keyword

NRG1; ErbB4; Global cerebral ischemia; Oxygen-glucose deprivation; Cell death

MeSH Terms

Anoxia
Brain
Brain Ischemia
Cell Death
Cognition
Hippocampus
Ischemia
Neuregulin-1
Neurons*
Neuroprotection
Neuroprotective Agents
Neuregulin-1
Neuroprotective Agents
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