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Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons

Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS

The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to...
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Pre-treated Populus tomentiglandulosa extract inhibits neuronal loss and alleviates gliosis in the gerbil hippocampal CA1 area induced by transient global cerebral ischemia

Park JH, Lee TK, Ahn JH, Shin BN, Cho JH, Kim IH, Lee JC, Kim JD, Lee YJ, Kang IJ, Hong S, Kim YH, Jeon YH, Lee YL, Won MH

The genus Populus (poplar) belonging to the Salicaceae family has been used in traditional medicine, and its several species show various pharmacological properties including antioxidant and anti-inflammatory effects. No study...
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Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils

Lee JC, Won MH

Experimentally transient global cerebral ischemia using animal models have been thoroughly studied and numerous reports suggest the involvement of oxidative stress in the pathogenesis of neuronal death in ischemic lesions....
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Changes of Glutamate Receptor Subunit Gene Expression in the Rat Hippocampus following Global Cerebral Ischemia

Lee SH, Kim JK, Bae CS, Chung YY, Cho KH

  • KMID: 2274988
  • Chonnam Med J.
  • 2001 Sep;37(3):219-224.
It has been well known that transient global ischemia of the brain induces delayed neuronal death of hippicampal CA1 pyramidal cells. Calcium influx is thought to play a critical role...
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Effects of glutamate receptor antagonists and protein synthesis inhibitor on delayed neuronal death induced by transient global ischemia in rat brain

Ko JS, Bae CS, Kim JK

  • KMID: 1849835
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):279-286.
It has been well documented that transient forebrain global ischemia causes selective neuronal degeneration in hippocampal CA1 pyramidal neurons with a delay of a few days. The mechanism of this delayed hippocampal CA1...
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Effects of blood glucose on ischemic brain damage in mature gerbils

Hong SH, Koo HS

  • KMID: 2342637
  • J Korean Neurol Assoc.
  • 1998 Apr;16(2):119-130.
BACKGROUND AND PURPOSE: Many clinical and experimental studies showed that in global ischemic encephalopathy, hyperglycemia consistently excacerbate ischemic brain damages with high mortality and morbidity. In contrast, the results of...
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Effects of Propofol and Halothane on Cerebral Metabolism and Brain Histopathologic Change Following Complete Cerebral Ischemia in Diabetic Rabbit

Kim JH, Lim C, Lim HJ, Chae BK, Chang SH

BACKGROUND: Because propofol has cerebral effects similar to barbiturates, it is postulated that propofol might offer more protection than halothane during cerebral ischemia. But there is no consistent data on...
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Effects of Mannitol and Thiopental on Regional Cerebral Blood Flow, Somatosensory Evoked Potential and Neurologic Outcome During Reperfusion Following Complete Global Cerebral Ischemia in Cats

Park CK, Lee SW, Park YS, Choi SJ, Huh PW, Chung DS, Kang JK, Choi CR

  • KMID: 2018872
  • J Korean Neurosurg Soc.
  • 1996 Feb;25(2):252-259.
The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental...
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Nitric Oxide Synthase Inhibition Alters Extracellular Glutamate Concentration after Global Cerebral Ischemia

Kil HY, Cho BJ, Piantadosi CA

No abstract available.
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The effect of hyperglycemia on lipid peroxidation in the global cerebral ischemia of the rat

Roh JK, Hong SB, Yoon BW, Kim MS, Myung HJ

To investigate the influence of hyperglycemia on ischemic brain damage, we measured brain ATP, lactate and malondialdehyde (MDA) levels in global cerebral ischemic models of Wistar rats. We induced...
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