- Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons
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Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS
- KMID: 2466700
- Anat Cell Biol.
- 2019 Dec;52(4):462-468.
- doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to... -
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- Neuregulin-1 Protects Neuronal Cells Against Damage due to CoCl2-Induced Hypoxia by Suppressing Hypoxia-Inducible Factor-1α and P53 in SH-SY5Y Cells
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Yoo SY, Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS
- KMID: 2467319
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S111-S118.
- doi: 10.5213/inj.1938190.095
PURPOSE: Hypoxia-mediated neurotoxicity contributes to various neurodegenerative disorders, including Alzheimer disease. Neuregulin-1 (NRG1) plays an important role in the development and plasticity of the brain. The aim of the present... -
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- Genome-Wide Association Studies of Autoimmune Thyroid Diseases, Thyroid Function, and Thyroid Cancer
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Hwangbo Y, Park YJ
- KMID: 2420484
- Endocrinol Metab.
- 2018 Jun;33(2):175-184.
- doi: 10.3803/EnM.2018.33.2.175
Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to have high heritability. Family and twin studies have indicated that genetics plays a major role in the development... -
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- The Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation
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Park SY, Jang SY, Shin YK, Jung DK, Yoon BA, Kim JK, Jo YR, Lee HJ, Park HT
- KMID: 2383783
- Exp Neurobiol.
- 2017 Jun;26(3):141-150.
- doi: 10.5607/en.2017.26.3.141
The vertebrate neuromuscular junction (NMJ) is considered as a “tripartite synapse†consisting of a motor axon terminal, a muscle endplate, and terminal Schwann cells that envelope the motor axon terminal.... -
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- Impact of Cell Density on Differentiation Efficiency of Rat Adipose-derived Stem Cells into Schwann-like Cells
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Najafabadi MM, Bayati V, Orazizadeh M, Hashemitabar M, Absalan F
- KMID: 2362515
- Int J Stem Cells.
- 2016 Nov;9(2):213-220.
- doi: 10.15283/ijsc16031
BACKGROUND AND OBJECTIVES: Schwann-like (SC-like) cells induced from adipose-derived stem cells (ASCs) may be one of the ideal alternative cell sources for obtaining Schwann cells (SCs). They can be used... -
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- Increased Expression of Neuregulin 1 and erbB2 Tyrosine Kinase in the Bladder of Rats With Cyclophosphamide-Induced Interstitial Cystitis
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Song KH, Youn CS, Lee CL, Yang SW, Chang YS, Jeong SW, Sul CK
- KMID: 2380844
- Int Neurourol J.
- 2015 Sep;19(3):158-163.
- doi: 10.5213/inj.2015.19.3.158
PURPOSE: The aim of this study was to evaluate changes in expressions of neuregulin (NRG)1 and erbB2 tyrosine kinase (ErbB2) in bladders of rats with cyclophosphamide (CYP)-induced interstitial cystitis (IC). METHODS:... -
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- Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity
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Lee HJ, Shin YK, Park HT
- KMID: 2165513
- Exp Neurobiol.
- 2014 Jun;23(2):130-137.
- doi: 10.5607/en.2014.23.2.130
Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves... -
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- Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population
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Yang SA
- KMID: 2165416
- Exp Neurobiol.
- 2012 Dec;21(4):158-163.
- doi: 10.5607/en.2012.21.4.158
Neuregulin 1 (NRG1) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors. Influence to schizophrenia development by the NRG1 gene may differ in individuals,... -
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- A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-beta1-induced MMP-1 and MMP-9 expression in breast cancer cells
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Kim S, Han J, Shin I, Kil WH, Lee JE, Nam SJ
- KMID: 1387358
- Exp Mol Med.
- 2012 Aug;44(8):473-482.
Overexpression of HER2 correlates with more aggressive tumors and increased resistance to cancer chemotherapy. However, a functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on tumor metastasis has not... -
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- Prepulse Inhibition of Startle Response: Recent Advances in Human Studies of Psychiatric Disease
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Takahashi , Hashimoto , Iwase M, Ishii R, Kamio Y, Takeda M
- KMID: 2171253
- Clin Psychopharmacol Neurosci.
- 2011 Dec;9(3):102-110.
Prepulse inhibition (PPI) is considered to be one of the most promising neurophysiological indexes for translational research in psychiatry. Impairment of PPI has been reported in several psychiatric diseases, particularly... -
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- Expression of ErbB4 in the neurons of Alzheimer's disease brain and APP/PS1 mice, a model of Alzheimer's disease
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Woo RS, Lee JH, Yu HN, Song DY, Baik TK
- KMID: 1447421
- Anat Cell Biol.
- 2011 Jun;44(2):116-127.
- doi: 10.5115/acb.2011.44.2.116
Neuregulin-1 (NRG1) plays important roles in the development and plasticity of the brain, and has also been reported to exhibit potent neuroprotective properties. Although ErbB4, a key NRG1 receptor, is... -
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- Expression of ErbB4 in the apoptotic neurons of Alzheimer's disease brain
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Woo RS, Lee JH, Yu HN, Song DY, Baik TK
- KMID: 1455348
- Anat Cell Biol.
- 2010 Dec;43(4):332-339.
- doi: 10.5115/acb.2010.43.4.332
Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain,... -
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- An Immunohistochemical Study of ErbB4 Receptor in Alzheimer's Disease Hippocampus
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Woo RS, Lee JH, Jung SS, Choy YJ, Yu HN, Oh KM, Song DY, Kwon J, Baik TK
- KMID: 1472475
- Korean J Anat.
- 2009 Dec;42(4):235-244.
Neuregulin-1 (NRG1) signaling participates in numerous neurodevelopmental processes. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain, little is known about its expression... -
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- Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo
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Lee HK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT
- KMID: 2071666
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):161-168.
- doi: 10.4196/kjpp.2009.13.3.161
In the peripheral nerves, injury-induced cytokines and growth factors perform critical functions in the activation of both the MEK/ERK and JAK/STAT3 pathways. In this study, we determined that nerve injury-induced... -
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- Expression of Heregulin and ErbB Family Proteins in Gastric Adenocarcinomas: Correlation with Clinopathologic Prognostic Factors
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Yoo CH, Lee JH, Choi JS
- KMID: 2372831
- J Korean Gastric Cancer Assoc.
- 2006 Sep;6(3):181-188.
PURPOSE: Heregulin is a natural ligand for erbB3 and erbB4. However, very little is known about their roles in the gastric cancer. This retrospective study was performed to evaluate the... -
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- Association of Genetic Variations within 5' end of Neuregulin 1 with Schizophrenia in Korean Population
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Park DY, Lee YS, Cho EY, Cho SH, Jang YL, Jeun HO, Jang SY, Yoon SC, Kim JW, Hong KS
- KMID: 2341075
- J Korean Neuropsychiatr Assoc.
- 2005 May;44(3):287-294.
OBJECTIVES: The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregulin 1 (NRG1) was identified in this locus as a positional... -
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- Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3
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Kim MS, Koland JG
- KMID: 1581029
- Korean J Physiol Pharmacol.
- 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular... -
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- Correlation of Heregulin mRNA and Her-2/neu Protein Expression with Node Metastasis and DNA Ploidy Pattern in Human Invasive Breast Carcinoma
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Kim YJ, Jung WH, Lee H, Lee SK, Moon IG, Lee KG
- KMID: 1725419
- Korean J Pathol.
- 1998 Aug;32(8):563-573.
The Her-2/neu protooncogene encodes a transmembrane tyrosine kinase that is structurally homologous to the receptor for epidermal growth factor. Its amplification and overexpression are associated with poor prognosis in breast... -
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