- Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
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Wang J, Bai T, Wang N, Li H, Guo X
- KMID: 2466565
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):11-18.
- doi: 10.4196/kjpp.2020.24.1.11
The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid... -
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- Targeted temperature management for ischemic stroke
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Hong JM
- KMID: 2470467
- J Neurocrit Care.
- 2019 Dec;12(2):67-73.
- doi: 10.18700/jnc.190100
Therapeutic hypothermia (TH) or targeted temperature management is an intentional cooling or temperature control technique using a thermostatic equipment (i.e., surface, endovascular, and focal devices) for specific therapeutic purposes. Given... -
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- Spinal Cord Injury and Neuro-Regeneration
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Ahn JH, Park HY, Kim YH
- KMID: 2469881
- J Korean Orthop Assoc.
- 2019 Dec;54(6):498-508.
- doi: 10.4055/jkoa.2019.54.6.498
Recent advances in the understanding of the pathophysiology of spinal cord injury (SCI) and new therapeutic approaches have provided promising results for this incurable and debilitating central nervous system injury.... -
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- Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons
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Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS
- KMID: 2466700
- Anat Cell Biol.
- 2019 Dec;52(4):462-468.
- doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- Cordycepin protects against β-amyloid and ibotenic acid-induced hippocampal CA1 pyramidal neuronal hyperactivity
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Yao LH, Wang J, Liu C, Wei S, Li G, Wang S, Meng W, Liu ZB, Huang LP
- KMID: 2461041
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):483-491.
- doi: 10.4196/kjpp.2019.23.6.483
Cordycepin exerts neuroprotective effects against excitotoxic neuronal death. However, its direct electrophysiological evidence in Alzheimer's disease (AD) remains unclear. This study aimed to explore the electrophysiological mechanisms underlying the protective... -
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- Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodefi ciency Mice: Preclinical Study
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Quesada MP, GarcÃa-Bernal D, Pastor D, Estirado A, Blanquer M, GarcÃa-Hernández AM, Moraleda J, MartÃnez
- KMID: 2464072
- Tissue Eng Regen Med.
- 2019 Oct;16(5):525-538.
- doi: 10.1007/s13770-019-00202-1
BACKGROUND: Mesenchymal stromal cells (MSCs) have potent immunomodulatory and neuroprotective properties, and have been tested in neurodegenerative diseases resulting in meaningful clinical improvements. Regulatory guidelines specify the need to perform... -
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- Management and prevention of third molar surgery-related trigeminal nerve injury: time for a rethink
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Leung YY
- KMID: 2461475
- J Korean Assoc Oral Maxillofac Surg.
- 2019 Oct;45(5):233-240.
- doi: 10.5125/jkaoms.2019.45.5.233
Trigeminal nerve injury as a consequence of lower third molar surgery is a notorious complication and may affect the patient in long term. Inferior alveolar nerve (IAN) and lingual nerve... -
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- Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends
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Hong N
- KMID: 2470030
- Biomed Eng Lett.
- 2019 Aug;9(3):359-366.
- doi: 10.1007/s13534-019-00115-x
Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be... -
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- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
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Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
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- Anti-inflammatory effect of aged black garlic on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice
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You BR, Yoo JM, Baek SY, Kim MR
- KMID: 2453282
- Nutr Res Pract.
- 2019 Jun;13(3):189-195.
- doi: 10.4162/nrp.2019.13.3.189
BACKGROUND/OBJECTIVES: Although aged black garlic has various biological activities such as anti-allergy, anti-inflammation and neuroprotection, effect of aged black garlic on chemically contact dermatitis is unclarified. MATERIALS/METHODS: To evaluate anti-dermatitic activity... -
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- Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia
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Park JM, Kim YJ
- KMID: 2451299
- J Korean Acad Nurs.
- 2019 Jun;49(3):317-328.
- doi: 10.4040/jkan.2019.49.3.317
PURPOSE: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. METHODS: Randomized controlled... -
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- tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?
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Kim JS
- KMID: 2449893
- J Stroke.
- 2019 May;21(2):160-174.
- doi: 10.5853/jos.2019.00584
Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is administered within 4.5... -
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- Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease
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Dietiker C, Kim S, Zhang Y, Christine , on behalf of the NINDS NET-PD Investigators
- KMID: 2449680
- J Mov Disord.
- 2019 May;12(2):91-96.
- doi: 10.14802/jmd.18049
OBJECTIVE: In Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability. Because little is known... -
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- Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death
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Cho CH, Byun HR, Jover-Mengual T, Pontarelli F, Dejesus C, Cho AR, Zukin RS, Hwang JY
- KMID: 2448803
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S11-S21.
- doi: 10.5213/inj.1938040.020
PURPOSE: Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment. Growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b)... -
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- Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
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Park JS, Leem YH, Park JE, Kim DY, Kim HS
- KMID: 2442009
- Biomol Ther.
- 2019 Feb;27(2):178-184.
- doi: 10.4062/biomolther.2018.234
Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether β-Lapachone (β-LAP), a... -
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- Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress
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Kang Y, Lee JH, Seo YH, Jang JH, Jeong CH, Lee S, Jeong GS, Park B
- KMID: 2442005
- Biomol Ther.
- 2019 Feb;27(2):145-151.
- doi: 10.4062/biomolther.2018.092
Methamphetamine (METH) acts strongly on the nervous system and damages neurons and is known to cause neurodegenerative diseases such as Alzheimer's and Parkinson's. Flavonoids, polyphenolic compounds present in green tea,... -
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- Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease
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Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z
- KMID: 2432069
- Biomol Ther.
- 2019 Jan;27(1):71-77.
- doi: 10.4062/biomolther.2018.051
Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this... -
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- Regulation of Neural Stem Cell Fate by Natural Products
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Kim HJ
- KMID: 2432062
- Biomol Ther.
- 2019 Jan;27(1):15-24.
- doi: 10.4062/biomolther.2018.184
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent... -
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- Cyanidin-3-glucoside inhibits amyloid β₂₅₋₃₅-induced neuronal cell death in cultured rat hippocampal neurons
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Yang JS, Jeon S, Yoon KD, Yoon SH
- KMID: 2430091
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):689-696.
- doi: 10.4196/kjpp.2018.22.6.689
Increasing evidence implicates changes in [Ca²âº]i and oxidative stress as causative factors in amyloid beta (Aβ)-induced neuronal cell death. Cyanidin-3-glucoside (C3G), a component of anthocyanin, has been reported to protect... -
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