J Korean Neurosurg Soc.  2019 May;62(3):321-327. 10.3340/jkns.2019.0005.

The Surgical and Cognitive Outcomes of Focal Cortical Dysplasia

Affiliations
  • 1Department of Pediatrics, Dankook University Hospital, Cheonan, Korea.
  • 2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 3Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea. pednr@snu.ac.kr

Abstract

Focal cortical dysplasia (FCD) is the major cause of intractable focal epilepsy in childhood leading to epilepsy surgery. The overall seizure freedom after surgery ranges between 50-75% at 2 years after surgery and the long-term seizure freedom remain relatively stable. Seizure outcome after surgery depends on a various factors such as pathologic etiologies, extent of lesion, and types of surgery. Therefore, seizure outcome after surgery for FCD should be analyzed carefully considering cohorts' characteristics. Studies of pediatric epilepsy surgery emphasize the early surgical intervention for a better cognition. Early surgical intervention and cessation of seizure activity are important for children with intractable epilepsy. However, there are limited data on the cognitive outcome after surgery in pediatric FCD, requiring further investigation. This paper reviews the seizure and cognitive outcomes of epilepsy surgery for FCD in children. Several prognostic factors influencing seizure outcome after surgery will be discussed in detail.

Keyword

Malformations of cortical development; Pediatrics; Epilepsy; Surgery; Patient outcome assessment

MeSH Terms

Child
Cognition
Drug Resistant Epilepsy
Epilepsies, Partial
Epilepsy
Freedom
Humans
Malformations of Cortical Development*
Patient Outcome Assessment
Pediatrics
Seizures

Reference

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