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External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old

Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS

BACKGROUND: Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2–12 years. There are few options for pharmacokinetic-pharmacodynamic model...
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Long-Term Efficacy of Anti-Tumor Necrosis Factor Agents in Pediatric Luminal Crohn's Disease: A Systematic Review of Real-World Evidence Studies

van Rheenen H, van Rheenen PF

PURPOSE: To determine the long-term efficacy of the anti-tumor necrosis factor (TNF) agents, infliximab (IFX) and adalimumab (ADA), in pediatric luminal Crohn's disease (CD) by performing a systematic literature review. METHODS:...
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Association of vitamin D deficiency with clinical outcomes in critically ill Korean children

Jhang WK, Kim DH, Park SJ

BACKGROUND/OBJECTIVES: Vitamin D is a pleiotropic hormone that affects various body organ systems. We evaluated the prevalence of a vitamin D deficiency (VDD) and its potential role in the clinical...
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The diagnostic usefulness and correlation of nasal eosinophil count and percentage in children with rhinitis

Yoon KH, Kim K, Yoon JS, Kim HH

PURPOSE: Allergic rhinitis is the most common atopic disease and the most common chronic disease of children. Eosinophil count and percentage in nasal smear are useful for differential diagnosis of...
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A Comparative Analysis of Clinical Screening Test and Language Specific Test in Language Delay Children

Lee NR, Chung SH, Song MK, Kong YH, Joo CU, Kim SJ

The aim of this study was to investigate the usefulness of a clinical screening test [the Korean Infant and Child Developmental Test (KICDT)] compared to language specific tests: the sequenced...
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Clinical and Laboratory Findings of Barley Allergy in Korean Children: a Single Hospital Based Retrospective Study

Lee E, Jeong K, Lee J, Jeon SA, Park B, Lee H, Lee S

BACKGROUND: Barley is a grain that is consumed in various forms in Asia. Studies on barley allergy are limited to a few case reports about hypersensitivity reactions to beer, but...
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Gastric Xanthoma in the Pediatric Population: A Possible Herald for Malignancy?

Russell JD, Peck J, Phen C, Linehan JL, Karjoo S, Nguyen J, Wilsey MJ

Gastric xanthoma is frequently an incidental finding on upper endoscopy in adults. Gastric xanthomas (GX) can be mistaken for malignancies and warrant prompt histologic diagnosis. The underlying etiology is not...
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Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts

Kang B, Kim JE, Jung JH, Choe JY, Kim MJ, Choe YH, Kim S, Koh H, Lee YM, Lee JH, Lee Y, Lee JH, Lee HJ, Jang HJ, Choi Y, Choi SY, Kim JY, Choe BH

PURPOSE: We aimed to investigate the disease phenotype of Korean pediatric Crohn's disease (CD) patients at diagnosis according to the Paris classification by comparison with patients from the European multicenter...
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Development of a physiologically-based pharmacokinetic model for cyclosporine in Asian children with renal impairment

Yoon S, Yi S, Rhee SJ, Lee HA, Kim Y, Yu KS, Chung JY

This study aimed to assess the pharmacokinetics of cyclosporine A (CsA) in Asian children with renal impairment (RI) by developing a physiologically-based pharmacokinetic (PBPK) model with Simcyp Simulator. The PBPK...
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Characteristics and Treatment Outcome of Intracranial Aneurysms in Children and Adolescents

Nam SM, Jang D, Wang KC, Kim SK, Phi JH, Lee JY, Cho WS, Kim JE, Kang HS

OBJECTIVE: Intracranial aneurysms are not common in young age patients. We sought to find the characteristics of the intracranial aneurysms in patients under 20 years of age. METHODS: We reviewed 23...
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How to Implement Quality Pediatric Palliative Care Services in South Korea: Lessons from Other Countries

Kim CH, Kim MS, Shin HY, Song IG, Moon YJ

PURPOSE: Pediatric palliative care (PPC) is emphasized as standard care for children with life-limiting conditions to improve the quality of life. In Korea, a government-funded pilot program was launched only...
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Hyo-Kyu Kim (1917–1999): The One Who Constructed Gangnam Severance Hospital and Reformed Yonsei University Health System

Kim BS

No abstract available.
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Calcifying Aponeurotic Fibroma in Dangerous Zone of Hand in Young Child

Hong SW, Choi HJ, Kim JH, Lee DW

Pediatric hand masses are often seen in outpatient department of the hospital. There are kinds of masses that can occur and it is important to discriminate between malignant and benign,...
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Long-term extracorporeal membrane oxygenation after severe blunt traumatic lung injury in a child

Lee OJ, Cho YH, Hwang J, Yoon I, Kim YH, Cho J

Managing acute respiratory distress syndrome (ARDS) after severe blunt traumatic lung injury can be challenging. In cases where patients are refractory to conventional therapy, extracorporeal membrane oxygenation (ECMO) should be...
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Incidentally detected gallbladder agenesis in a child: the importance of identifying anatomic structure

Jung JH, Suh HR, Lee DE, Choe JY, Lee SM, Kang B, Choe BH

The absence of a gallbladder is a very rare anomaly. While it is usually asymptomatic, it can cause biliary colic symptoms. For these reasons, gallbladder agenesis can be misdiagnosed as...
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Comparison of the Postoperative Outcome for Pediatric Obstructive Sleep Apnea According to the Type of the Tonsillectomy

Cho KR, Sohn JH

BACKGROUND AND OBJECTIVES: Partial intracapsular tonsillectomy and adenoidectomy (PITA) has become a well-recognized technique for tonsillectomy in children. Several studies have reported that PITA shows better postoperative morbidity compared to...
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Epidemiology of violence in pediatric and adolescent nasal fracture compared with adult nasal fracture: An 8-year study

Yu H, Jeon M, Kim Y, Choi Y

BACKGROUND: The epidemiology of nasal fractures varies according to factors such as the era and area of the study, as well as the age of the patient. We compared the...
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Evaluation of hematologic profile may be needed for patients treated with oxcarbazepine

Jung GH, You SJ

PURPOSE: The major side effects of treatment with oxcarbazepine (OXC) are skin rash and hyponatremia. Hematologic side effects are reported rarely. The aim of this study was to investigate the...
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Bayesian Approach to Predicting Acute Appendicitis Using Ultrasonographic and Clinical Variables in Children

Reddan T, Corness J, Harden F, Hu W, Mengersen

OBJECTIVES: Ultrasound has an established role in the diagnostic pathway for children with suspected appendicitis. Relevant clinical information can influence the diagnostic probability and reporting of ultrasound findings. A Bayesian...
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Prediction and Staging of Hepatic Fibrosis in Children with Hepatitis C Virus: A Machine Learning Approach

Barakat NH, Barakat SH, Ahmed N

OBJECTIVES: The aim of this study is to develop an intelligent diagnostic system utilizing machine learning for data cleansing, then build an intelligent model and obtain new cutoff values for...
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