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Multidimensional Early Prediction Score for Drug-Resistant Epilepsy

Kang KW, Cho YW, Lee SK, Jung KY, Kim JH, Kim DW, Lee SA, Hong SB, Na IS, Lee SH, Baek WK, Choi SY, Kim MK

Background and Purpose Achieving favorable postoperative outcomes in patients with drug-resistant epilepsy (DRE) requires early referrals for preoperative examinations. The purpose of this study was to investigate the possibility of...
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Effects of Cannabidiol on Adaptive Behavior and Quality of Life in Pediatric Patients With Treatment-Resistant Epilepsy

Kim SH, Choi HS, Koo CM, Joo BR, Park BJ, Lee HK, Lee JS, Kim HD, Kang HC

Background and Purpose Data regarding the effects of cannabidiol (CBD) on the quality of life (QOL) are currently inadequate. We assessed the QOL of pediatric patients with epilepsy who were...
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Clinical Usefulness of Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging in Children With Focal Epilepsy

Lee YJ, Bae H, Byun JC, Kwon S, Oh SS, Kim S

Background and Purpose The current study analyzed the interictal epileptiform discharge (IED)-related hemodynamic response and aimed to determine the clinical usefulness of simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI)...
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Effectiveness of the Use of Standardized Vocabularies on Epilepsy Patient Cohort Generation

Jung H, Lee HY, Yoo S, Hwang H, Baek H

Objectives: This study investigated the effectiveness of using standardized vocabularies to generate epilepsy patient cohorts with local medical codes, SNOMED Clinical Terms (SNOMED CT), and International Classification of Diseases tenth...
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Dysembryoplastic Neuroepithelial Tumor: A Benign but Complex Tumor of the Cerebral Cortex

Phi JH, Kim SH

Dysembryoplastic neuroepithelial tumor (DNET) is a distinct type of low-grade glioneuronal tumor. Clinically, DNET is highly associated with intractable epilepsy in young children and adolescents. Therefore, the burden of the...
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Big data analysis and artificial intelligence in epilepsy – common data model analysis and machine learning-based seizure detection and forecasting

Chung YG, Jeon Y, Yoo S, Kim H, Hwang H

There has been significant interest in big data analysis and artificial intelligence (AI) in medicine. Ever-increasing medical data and advanced computing power have enabled the number of big data analyses...
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Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs

Byun JI, Sunwoo JS, Kang KW, Kim KT, Kim D, Kim DW, Kim S, Kim SH, Kim W, Moon HJ, Park HR, Seo JG, Chu MK, Hwang KJ, Seo DW,

Several medications are approved to treat coronavirus disease 2019 (COVID-19) in Korea including nirmatrelvir/ritonavir, remdesivir, and regdanvimab. There is potential drug-drug interaction between antiepileptic drugs (AEDs) and the medications used...
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Effects of Vagus Nerve Stimulation on Sleep-Disordered Breathing, Daytime Sleepiness, and Sleep Quality in Patients With Drug-Resistant Epilepsy

Kim JS, Lee DE, Bae H, Song JY, Yang KI, Hong SB

Background and Purpose This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) on sleep-disordered breathing (SDB), daytime sleepiness, and sleep quality in patients with drug-resistant epilepsy...
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Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study

Dziedzic TA, Koczyk K, Nowak A, Maj E, Marchel A

Objective : Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The...
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Trends in Prescribing of Antiseizure Medications in South Korea: Real-World Evidence for Treated Patients With Epilepsy

Kang KW, Lee H, Shin JY, Moon HJ, Lee SY

Background and Purpose We investigated the trends in the prescribing of antiseizure medication (ASM) over a 9-year period, and provide real-world data regarding ASM prescriptions of patients with epilepsy in...
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Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain

Ko A, Sim NS, Choi HS, Yang D, Kim SH, Lee JS, Kim DS, Lee JH, Kim HD, Kang HC

Background and Purpose A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of the proposed mechanisms of action is that the KD inhibits the mammalian target of rapamycin...
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Effective ketogenic diet in CACNA1A-related ‘epilepsy of infancy with migrating focal seizures’

Na H, Lee S, Kim YO

Genetic causes of developmental and epileptic encephalopathy (DEE) have been rapidly uncovered from mid-2010s. The mutations of gene enconding calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A) are recently...
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Two Focal Seizure in a Patient Caused by Different Mechanism

Kim HJ, Ryu HU, Shin BS, Kang HG

Poststroke epilepsy is the most common cause of epilepsy in adult. Acute symptomatic seizure is a provoked seizure usually caused by systemic metabolic disorders. If stroke patient has a seizure,...
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Practical Drug Treatment Recommendations on the Drug Refractory Epilepsy Patients: 2021 Clinical Guideline Subcommittee for Epilepsy in the Korean Neurological Association

Shin DJ, Shon YM, Jung KY, Koo YS, Kim D, Seo JG, Kim J, Song HK

One third of the overall epilepsy population are estimated to be a drug refractory epilepsy (DRE), defined as the patients who failed to control seizure reduction, even tried two or...
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Is it really a seizure? The challenge of paroxysmal nonepileptic events in young infants

Jung SY, Kang JW

Paroxysmal nonepileptic events (PNE) comprise of a variety of nonepileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by...
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Increasing Trends in the Incidence and Prevalence of Epilepsy in Korea

Jeon JY, Lee H, Shin JY, Moon HJ, Lee SY, Kim JM, on behalf of Epidemiology Committee of Korean Epilepsy Society

Background and Purpose There have been few reports on recent trends in the occurrence of epilepsy. The aim of this study was to estimate the incidence and prevalence of epilepsy...
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Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy

Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB

Background and Purpose This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) treatment on suicidality, mood-related symptoms, and quality of life (QOL) in patients with drug-resistant...
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Gamma-Knife Radiosurgery for Hypothalamic Hamartoma-Related Epilepsy

Song JY, Lee JI, Shin HJ, Lee J, Lee J

Purpose: Hypothalamic hamartoma (HH), a rare congenital disorder, can cause intractable epilepsy and requires optimal surgical treatment. This study analyzed the clinical characteristics of HH and evaluated seizure outcomes and...
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Concept Analysis of Parents’ Treatment Adherence for an Epileptic Child or Adolescent

Lee J, Yoon JY

Purpose: This concept analysis was conducted to clarify ‘parents’ treatment adherence for an epileptic child or adolescent’. Methods: The analysis used a hybrid model comprising three phases: theoretical phase, fieldwork...
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Treatment strategies targeting specific genetic etiologies in epilepsy

Kim HJ, Kang HC

Recent genetic advances allow for identification of the genetic etiologies of epilepsy within individual patients earlier and more frequently than ever. Specific targeted treatments have emerged from improvements in understanding...
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