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Increasing Trends in the Incidence and Prevalence of Epilepsy in Korea

Jeon JY, Lee H, Shin JY, Moon HJ, Lee SY, Kim JM, on behalf of Epidemiology Committee of Korean Epilepsy Society

Background and Purpose There have been few reports on recent trends in the occurrence of epilepsy. The aim of this study was to estimate the incidence and prevalence of epilepsy...
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Effect of Long-Term Treatment with Vagus Nerve Stimulation on Mood and Quality of Life in Korean Patients with Drug-Resistant Epilepsy

Kim JS, Kim DY, Jo HJ, Hwang YH, Song JY, Yang KI, Hong SB

Background and Purpose This study aimed to determine the long-term effects of vagus nerve stimulation (VNS) treatment on suicidality, mood-related symptoms, and quality of life (QOL) in patients with drug-resistant...
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Gamma-Knife Radiosurgery for Hypothalamic Hamartoma-Related Epilepsy

Song JY, Lee JI, Shin HJ, Lee J, Lee J

Purpose: Hypothalamic hamartoma (HH), a rare congenital disorder, can cause intractable epilepsy and requires optimal surgical treatment. This study analyzed the clinical characteristics of HH and evaluated seizure outcomes and...
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Treatment strategies targeting specific genetic etiologies in epilepsy

Kim HJ, Kang HC

Recent genetic advances allow for identification of the genetic etiologies of epilepsy within individual patients earlier and more frequently than ever. Specific targeted treatments have emerged from improvements in understanding...
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Current Pharmacologic Strategies for Treatment of Intractable Epilepsy in Children

Moon JU, Cho KO

Epileptic encephalopathy (EE) is a devastating pediatric disease that features medically resistant seizures, which can contribute to global developmental delays. Despite technological advancements in genetics, the neurobiological mechanisms of EEs...
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Psychoses of Epilepsy in Pregnancy: A Case Report

Fahed M, Ramanathan S

To discuss the unique relationship between psychosis and seizures in a young individual, who is also pregnant. Psychosis of epilepsy can present in multitude of ways, including pre-ictal, ictal, post-ictal,...
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Tectal glioma presenting with adult-onset epileptic seizures

Kim JH, Jo H, Choi JW, Joo EY

Tectal glioma is an indolent and benign tumor that occurs predominantly in the pediatric population. It arises in the tectum of the midbrain and, due to its location, contributes to...
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Ketamine-induced generalized convulsive seizure during procedural sedation

Kim JH, Lee CK, Yu SH, Min BD, Chung CE, Kim DC

Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects,...
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Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy

Lu E, Pyatka N, Burant CJ, Sajatovic M

Background and Purpose Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon...
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Clinical and Genetic Spectrum of STXBP1 Encephalopathy in the Korean Pediatric Population

Kim WJ, Shim YK, Ko YJ, Kim SY, Kim H, Lim BC, Hwang H, Choi J, Kim KJ, Chae JH

Purpose: Syntaxin-binding protein 1 (STXBP1) mutations are known to result in various phenotypes including Ohtahara syndrome, West syndrome, and autism, collectively referred as STXBP1 encephalopathy. This study aimed to expand...
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Once-Daily Extended-Release Levetiracetam Improves Medication Compliance in Adolescent Epilepsy Patients

Jung SY, Yi YY, Kang JW

Purpose: Since pharmacologic agents are the mainstay of epilepsy treatment, drug compliance is one of the most important factors in seizure control. Once-daily levetiracetam (LEV) has been proven to have...
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Modulatory Potential of LncRNA Zfas1 for Inflammation and Neuronal Apoptosis in Temporal Lobe Epilepsy

He C, Su C, Zhang W, Zhou Q, Shen X, Yang J, Shi N

Purpose: This study aimed to elucidate whether lncRNA ZFAS1 is involved in neuronal apoptosis and inflammation in temporal lobe epilepsy (TLE). Materials and Methods: Ninety-six TLE patients were recruited, and their...
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The Early Response to Dietary Therapy can Predict the Late Outcome in Children with Intractable Epilepsy

Lim Sy, Yum MS, Ahn H, Kim MJ, Jang HN, Ko TS

Background and Purpose Dietary therapy (DT), including the ketogenic diet (KD), is one of the nonpharmacological treatment options for patient with drug-resistant epilepsy. However, maintaining DT in patients without seizure...
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Clinical Characteristics of Epilepsy and Its Risk Factors in Neurofibromatosis Type 1: A Single-Center Study

Shin A, Byun JC, Hwang SK, Kwon S, Lee YJ

Purpose: This study investigated the clinical characteristics and risk factors of epilepsy in patients with neurofibromatosis type 1 (NF1) at a tertiary center. Methods: The medical records of 103 children...
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Screening of Tuberous Sclerosis-Associated Neuropsychiatric Disorders in Korea Using the TAND Checklist

Park S, Eom S, Kang HC, Lee JS, Kim HD, Chung HJ

Purpose: The present study aimed to elucidate the clinical characteristics of children with tuberous sclerosis complex (TSC) in Korea using the Tuberous Sclerosis-Associated Neuropsychiatric Disorders (TAND) checklist to evaluate the...
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Recurrence of Epilepsy and Related Risk Factors after the Discontinuation of Antiepileptic Drugs in Children: A 10-Year Single-Center Study

Choi JH, Kim SJ

Purpose: The criteria for discontinuing antiepileptic drugs (AEDs) in children with well-controlled epilepsy remain unclear. This study sought to identify the recurrence rate of epilepsy after the discontinuation of AEDs...
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Risk Factors for Chronic Kidney Disease in Pediatric Patients with Epilepsy

Pak J, Byeon JH, Yim CH, Eun BL

Purpose: The aim of the treatment of epileptic seizures is to achieve a seizure-free state without adverse effects. The mainstays of seizure treatment are anticonvulsant medication, diet therapy, and surgery....
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Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum

Seo JH, Lee YJ, Lee KH, Gireesh E, Skinner H, Westerveld M

Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The...
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Bleeding properties according to surgical sites during pediatric craniotomy: a retrospective study comparing the two stages of epilepsy surgery

Lee B, Bae MI, Eum D, Ntungi AM, Jun B, Min KT

Background: During pediatric epilepsy surgery, due to low circulating blood volume, intraoperative bleeding can result in significant hemodynamic instability, thereby requiring meticulous hemodynamic and transfusion strategies. Knowing the source of...
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Efficacy and Safety of Lacosamide in Adolescents with Lennox-Gastaut Syndrome

Choi HS, Kim SH, Kang HC, Lee JS, Kim HD

Purpose: We aimed to assess the efficacy and safety of lacosamide in Korean adolescents with Lennox-Gastaut syndrome (LGS), especially in those who concomitantly used other sodium channel blockers (SCBs). Methods:...
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