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Focal Cortical Dysplasia in Pediatric Epilepsy

Choi SA, Kim KJ

Focal cortical dysplasia (FCD) is the most common cause of intractable focal epilepsy in children undergoing epilepsy surgery. In these patients, seizures usually develop in early childhood and are often...
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The Surgical and Cognitive Outcomes of Focal Cortical Dysplasia

Choi SA, Kim KJ

Focal cortical dysplasia (FCD) is the major cause of intractable focal epilepsy in childhood leading to epilepsy surgery. The overall seizure freedom after surgery ranges between 50–75% at 2 years...
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Pathological Classification of Focal Cortical Dysplasia (FCD) : Personal Comments for Well Understanding FCD Classification

Kim SH, Choi J

In 2011, the International League against Epilepsy (ILAE) proposed a first international consensus of the classification of focal cortical dysplasia (FCD). This FCD classification had been widely used in worldwide....
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Antiepileptic Drug Withdrawal after Surgery in Children with Focal Cortical Dysplasia: Seizure Recurrence and Its Predictors

Choi SA, Kim SY, Kim WJ, Shim YK, Kim H, Hwang H, Choi JE, Lim BC, Chae JH, Chong S, Lee JY, Phi JH, Kim SK, Wang KC, Kim KJ

BACKGROUND AND PURPOSE: This study investigated the seizure recurrence rate and potential predictors of seizure recurrence following antiepileptic drug (AED) withdrawal after resective epilepsy surgery in children with focal cortical...
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Discontinuing Antiepileptic Drugs after Pediatric Epilepsy Surgery for Focal Cortical Dysplasia

Seo SE, Kim SH, Kim DS, Kang HC, Lee JS, Kim HD

PURPOSE: Antiepileptic drugs (AEDs) can be discontinued in a subset of patients after surgery. We aimed to identify the factors related to successful AED withdrawal after surgery in pediatric patients...
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Malformations of cortical development: genetic mechanisms and diagnostic approach

Lee J

Malformations of cortical development are rare congenital anomalies of the cerebral cortex, wherein patients present with intractable epilepsy and various degrees of developmental delay. Cases show a spectrum of anomalous...
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Molecular genetic decoding of malformations of cortical development

Lim JS, Lee JH

Malformations of cortical development (MCD) cover a broad spectrum of developmental disorders which cause the various clinical manifestations including epilepsy, developmental delay, and intellectual disability. MCD have been clinically classified...
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Emerging Surgical Strategies of Intractable Frontal Lobe Epilepsy with Cortical Dysplasia in Terms of Extent of Resection

Shin JH, Jung NY, Kim SP, Son EI

OBJECTIVE: Cortical dysplasia (CD) is one of the common causes of epilepsy surgery. However, surgical outcome still remains poor, especially with frontal lobe epilepsy (FLE), despite the advancement of neuroimaging...
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A Case of Central Diabetes Insipitus Combined with Septo-Optic Dysplasia and Schizencephaly in 31-year-old Woman

Kim SK, Jung TS, Hahm JR, Lee SM, Moon SW, Lee KJ, Chung SI

A 31-year-old woman was referred to our hospital for evaluation and management of poorly controlled epilepsy. The patient had been taking anti-epileptic drugs for six years. An MRI imaging study...
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Cortical Dysplasia and Microdysgenesis; Correlations between Clinical Feaures, Neuroimaging and Electrophysiology after Lobectomy for Intractable Epilepsy in Children

Lee EB, Hur YJ, Kim SH, Kim DS, Lee SK, Kim HD, Lee JS

  • KMID: 1528181
  • J Korean Child Neurol Soc.
  • 2007 May;15(1):45-57.
PURPOSE: The diagnosis of cortical dysplasia(CD) and microdysgenesis(MD) is valuable because they often cause childhood intractable epilepsy. This study is to analyze clinical manifestations, EEG findings, and imaging features based...
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Cortical Dysplasia of Brain: 2 Autopsy Cases

Kwon TJ, Kim YH, Kim DH

  • KMID: 2082668
  • Korean J Leg Med.
  • 2006 Oct;30(2):123-128.
Cortical dysplasia is used to designate any cerebral developmental malformation, and encompass a spectrum of pathologic changes from mild cortical disruption to more severe pattern of cortical dyslamination with large...
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A Case of Klippel-Trenaunay-Weber Syndrome with Facial Hemihypertrophy and Hemimegalencephaly

Jang HS, Lee SY, Lee YJ

  • KMID: 2329356
  • J Korean Child Neurol Soc.
  • 2006 May;14(1):169-174.
Klippel-Trenaunay-Weber syndrome(KTWS) is a rare, and sporadically occurring disorder characterized by hemihypertrophy(unilateral limb hypertrophy), varicose veins, hemangiomas and occasionally arteriovenous malformations. In 1900, noted French physicians Klippel and Trenaunay first...
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A Case of Infantile Nystagmus in a Child with Schizencephaly

Kim CH, Lew H, Yun YS, Kim MY

  • KMID: 2337339
  • J Korean Ophthalmol Soc.
  • 2006 Apr;47(4):678-682.
PURPOSE: Nystagmus is a rare involuntary eye movement which has no known, specific, underlying diseases. Schizencephaly is also a rare disease. A child with generalized developmental delay came to the...
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A Case of Neurofibromatosis Type 1 with Cortical Dysplasia

Lee JS, Kim SH, Kim HM, Park SY, Lee JH, Chae JH, Kim KJ, Hwang YS, Kim IO

  • KMID: 2329330
  • J Korean Child Neurol Soc.
  • 2005 Nov;13(2):276-281.
Neurofibromatosis type 1(NF1) is the most common neurocutaneous syndrome which has an autosomal dominant pattern of inheritance. The NF1 gene is located on chromosome 17q11.2 and encodes for neurofibromin known...
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Schizencephaly Suspected as Normal Tension Glaucoma on Ophthalmoscopic Examination

Yoo S, Lee J

  • KMID: 2125920
  • J Korean Ophthalmol Soc.
  • 2004 Oct;45(10):1761-1766.
PURPOSE: Occasionally, in nonglaucomatous optic atrophy, the optic nerve head may appear to be cupped to such a degree that normal tension glaucoma is suspected. We report such a case...
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Role of Apoptosis in Development of Experimental Rat Cerebral Cortical Dysplasia

Lee YJ, Chung CK

  • KMID: 2181951
  • J Korean Epilepsy Soc.
  • 2003 Dec;7(2):101-107.
Microgyria is one type of cortical dysplasia with dyslaminations and anomalous cell densities, which could be produced experimentally. In a normal rat cortical development, overproduced neuroblasts gradually die by apoptosis....
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MR Imaging Findings of Cortical Dysplasia of the Brain: Correlation with Pathologic Grades and Subtypes

Kwon BJ, Chang KH, Chung CK, Han MH, Choi YL, Chi JG

  • KMID: 1516299
  • J Korean Soc Magn Reson Med.
  • 2003 Jun;7(1):47-55.
PURPOSE: Cortical dysplasia is known to be of variety of MR imaging findings. We attempted to classify MR imaging findings of cortical dysplasia into several types and to correlate those...
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Curved Planar Reconstruction of MR Images in Focal Cortical Dysplasia of the Brain

Chung GH, Lee SY, Kim CS, Kim YK, Lee YH, Jeong SH

PURPOSE: To describe curved planar reconstruction imaging (CPRI) and determine its usefulness in the evaluation of focal cortical dysplasia of the brain. MATERIALS AND METHODS: In 17 cases of focal cortical...
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A Case of Antenatally Detected Schizencephaly

Jeong BJ, Lee KS, Choong EJ, Hwang JS, Kim YH

  • KMID: 2262683
  • Korean J Obstet Gynecol.
  • 2002 Mar;45(3):529-532.
Schizencephaly is an unusual condition rarely detected antenatally. It is a neuronal migrational disorder consisting of clefts in the brain that communicate with the lateral ventricles. The etiology and the...
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Surgically Treated Intractable Child Epilepsy with Focal Cortical Dysplasia : Clinical and Electroencephalographic Findings

Chung SH, Lee HY, Lee MH, Yoon HK, Kim BK, Hong SC

  • KMID: 2207446
  • J Korean Pediatr Soc.
  • 2001 May;44(5):552-561.
PURPOSE: Widespread use of MRI now gives us increased insights into the different expressions of cortical malformations. We carried out this study to characterize the clinical and EEG features of...
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