J Obes Metab Syndr.  2018 Mar;27(1):4-24. 10.7570/jomes.2018.27.1.4.

Sleep and Obesity

• Ding C
• Lim LL
• Xu L
• Kong AP

• KMID: 2410871
• DOI: http://doi.org/10.7570/jomes.2018.27.1.4

Abstract

Rising global prevalence and incidence of obesity lead to increased cardiovascular-renal complications and cancers. Epidemiological studies reported a worldwide trend towards suboptimal sleep duration and poor sleep quality in parallel with this obesity epidemic. From rodents and human models, it is highly plausible that abnormalities in sleep, both quantity and quality, impact negatively on energy metabolism. While excess dietary intake and physical inactivity are the known drivers of the obesity epidemic, promotion of healthy sleep habits has emerged as a new target to combat obesity. In this light, present review focuses on the existing literature examining the relationship between sleep physiology and energy homeostasis. Notably, sleep dysregulation perturbs the metabolic milieu via alterations in hormones such as leptin and ghrelin, eating behavior, neuroendocrine and autonomic nervous systems. In addition, shift work and trans-meridian air travel may exert a negative influence on the hypothalamic-pituitary-adrenal axis and trigger circadian misalignment, leading to impaired glucose tolerance and increased fat accumulation. Amassing evidence has also suggested that uncoupling of the circadian clock can increase the risk of adverse metabolic health. Given the importance of sleep in maintaining energy homeostasis and that it is potentially modifiable, promoting good sleep hygiene may create new avenues for obesity prevention and treatment.

Keyword

Sleep; Energy metabolism; Leptin; Ghrelin; Pituitary-adrenal system; Circadian rhythm

MeSH Terms

Autonomic Nervous System
Circadian Clocks
Circadian Rhythm
Energy Metabolism
Epidemiologic Studies
Feeding Behavior
Ghrelin
Glucose
Homeostasis
Humans
Hygiene
Incidence
Leptin
Obesity*
Physiology
Pituitary-Adrenal System
Prevalence
Rodentia
Ghrelin
Glucose
Leptin