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A Patient with the Disrupted Sleep-Wake Rhythm after Traumatic Brain Injury

Kim E, Kim S, Lee JH

Many patients with a traumatic brain injury (TBI) experience a range of sleep problems. Although some studies investigated the pathophysiology of sleep-wake cycle disturbances in TBI patients, it has not...
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Is Advancing Circadian Rhythm the Mechanism of Antidepressants?

Lee HJ

Antidepressants usually require 2–8 weeks after drug administration to obtain a clinical response. In contrast, three fast-acting antidepressant treatments (sleep deprivation, electroconvulsive therapy, and ketamine) significantly reduced depressive symptoms within...
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Effects of Light on Daytime Sleep in 12 Hours Night Shift Workers: A Field Study

Choi SJ, Park HR, Joo EY

OBJECTIVES: Night shift workers suffer from sleep and daytime disturbances due to circadian misalignment. To investigate the role of environmental light in daytime sleep following 12 h-night shift work. METHODS: We...
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Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells

Jo SH, Lee SH, Kim KT, Choi SY

Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial...
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Characterization of circadian blood pressure patterns using non-linear mixed effects modeling

Chae D, Kim Y, Park K

Characterizing the time course of baseline or pre-drug blood pressure is important in acquiring unbiased estimates of antihypertensive drug effect. In this study, we recruited 23 healthy male volunteers and...
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Treadmill Exercise Alleviates Circadian Rhythm Disruption-Induced Memory Deficits by Activation of Glucocorticoid Receptor and Brain-Derived Neurotrophic Factor-Dependent Pathway

Kim SE, Ko IG, Ji ES, Jin JJ, Hwang L, Kim SH, Cho S, Kim CJ, Kim K, Kim KH

PURPOSE: Circadian rhythm affects learning process, memory consolidation, and long-term memory. In this study, the alleviating effect of exercise on circadian rhythm disruption-induced memory deficits was investigated. METHODS: BMAL1 knockdown transgenic...
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The Influence of Chronotype and Self-Efficacy on Problem Drinking in Undergraduate Students

Kim JH, Song Y

PURPOSE: The aim of this study is to identify the influence of chronotype and self-efficacy on drinking problem in undergraduate students. METHODS: A cross-sectional survey design was adopted for the 177...
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Influence of Circadian Disruption Associated With Artificial Light at Night on Micturition Patterns in Shift Workers

Kim SJ, Kim JW, Cho YS, Chung KJ, Yoon H, Kim KH

Shift workers often experience problems associated with circadian disruption associated with artificial light at night and nocturia is commonly noted in night-shift workers. Nocturia associated with circadian disruption is due...
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Altered Regional Cerebral Blood Flow Associated with Mood and Sleep in Shift Workers: Cerebral Perfusion Magnetic Resonance Imaging Study

Park YK, Kim JH, Choi SJ, Kim ST, Joo EY

BACKGROUND AND PURPOSE: Shift work disrupts the body's circadian rhythms and increases the risk of health problems. Despite evidence of neuropsychological disturbances in shift workers (SW), the brain functional status...
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Night shiftwork and prostate-specific antigen level in a tire manufacturing factory

Cho S, Park WJ, Kang W, Lim DY, Kim S, Moon JD

BACKGROUND: Recent studies suggest that night shiftwork may increase the risk of prostate cancer and elevated serum prostate-specific antigen (PSA) level. The purpose of this study was to verify whether...
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Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder

Moon E, Choe BM, Park JM, Chung YI, Lee BD, Park JH, Lee YM, Jeong HJ, Cheon Y, Choi Y, Park J

OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC)...
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Validation of the Munich ChronoType Questionnaire in Korean Older Adults

Ryu H, Joo EY, Choi SJ, Suh S

OBJECTIVE: This study aimed to evaluate psychometric properties of the Munich ChronoType Questionnaire (MCTQ) in a sample of Korean older adults. METHODS: One-hundred ninety two participants aged 65 and over completed...
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Electroconvulsive Seizure Alters the Expression and Daily Oscillation of Circadian Genes in the Rat Frontal Cortex

Kim SH, Park HG, Jeong SH, Kang UG, Ahn YM, Kim YS

OBJECTIVE: Electroconvulsive therapy (ECT) is the most effective treatment for mood disorders. Accumulating evidence has suggested the important role of circadian genes in mood disorders. However, the effects of ECT...
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Is Advancing of Circadian Rhythm a Reason for the Rapid Treatment Effect of Electroconvulsive Therapy?

Lee HJ

No abstract available.
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Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2

Kim M, de la Peña JB, Cheong JH, Kim HJ

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the...
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A Case of Circadian Rhythm Sleep-Wake Disorder in Partial Blindness

Kim H, Park J, Kim JB

Although it is well known that sleep disturbances can be developed in complete blindness, normally entrained circadian rhythm was observed in the majority of patients with partial blindness. Here, we...
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A Nationwide Survey of Shift Schedules for Sleep Technicians in Korea

Lee SY, Choi SJ, Suh S, Song P, Joo EY, Shift Work Disorder Study Group

OBJECTIVES: It is a paradox that sleep technicians are at risk of shift work sleep disorder to help diagnose other people's sleep disorder. Until now, there have been no guidelines...
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Distinct Ultradian Rhythms in Plasma Clusterin Concentrations in Lean and Obese Korean Subjects

Choi JH, Jeong E, Youn BS, Kim MS

BACKGROUND: Blood levels of many hormones show rhythmic fluctuations with variable duration of cycles. Clusterin/apolipoprotein J is a glycoprotein which is highly expressed in the plasma and has modulatory roles...
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The Effect of Circadian and Sleep Disruptions on Obesity Risk

Noh J

The prevalence of obesity continues to increase worldwide. Multiple risk factors and complex mechanisms are involved in the development and maintenance of obesity. Recently, emerging evidence has indicated that the...
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Sleep and Obesity

Ding C, Lim LL, Xu L, Kong AP

Rising global prevalence and incidence of obesity lead to increased cardiovascular-renal complications and cancers. Epidemiological studies reported a worldwide trend towards suboptimal sleep duration and poor sleep quality in parallel...
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