Korean J Psychopharmacol.  2011 Jan;22(1):23-28.

A Study of Antidepressant and Mood Stabilizer's Effect on Phase of Peripheral Circadian Rhythm in Rat Fibroblast

• Koh SH
• Noh JS

Abstract

OBJECTIVE
Circadian rhythm is cyclic variations in biological activity, which is crucial for physiology in mammals and alterations in circadian rhythm may be related to mood disorders. However, the effect of mood disorder medications on peripheral tissue is less understood. In this study, we investigated whether treatment with antidepressants, antipsychotics, and mood stabilizers in rat fibroblast influenced circadian rhythm.
METHODS
Lithium, bupropion, risperidone, lamotrigine, and paroxetine were used on cultured NIH3T3, peripheral rat fibroblast and we observed the periodic oscillation and rhythmicity of Per2, Bmal1 mRNA for 48 hours.
RESULTS
We found that lithium has a dose-dependent effect on phase change of circadian rhythm and buproipion has a tendency to dampen the amplitude. Risperidone, lamotrigine, and paroxetine had no influence on circadian rhythm in NIH3T3 cell.
CONCLUSION
These results suggest that lithium treatment may have an effect on circadian rhythm lengthening in peripheral fibroblast tissue.

Keyword

Circadian rhythm; Clock; Fibroblast; Mood disorder; NIH3T3; Antidepressants

MeSH Terms

Animals
Antidepressive Agents
Antipsychotic Agents
Bupropion
Circadian Rhythm
Fibroblasts
Lithium
Mammals
Mood Disorders
Paroxetine
Periodicity
Rats
Risperidone
RNA, Messenger
Triazines
Antidepressive Agents
Antipsychotic Agents
Bupropion
Lithium
Paroxetine
RNA, Messenger
Risperidone
Triazines