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Physical and biological assessment of a novel resin for digital light processing

Lee JH, Ham SJ, Shin JW, Jeong CW, Choi JI, Kim YJ

The current study introduces photocurable macromolecular resin (KIS resin) and aims to assess its use as a basic material for implant surgical stent fabrication using 3D printing and the digital...
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IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis

Wang H, Wu T, Hua F, Sun J, Bai Y, Wang W, Liu J, Zhang M

BACKGROUND: Recent evidence suggests that IL-33, a novel member of the IL-1b family, is involved in organ fibrosis. However, the roles of IL-33 and its receptor ST2 in epidural fibrosis...
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Use of Human Gingival Fibroblasts for Pre-Vascularization Strategies in Oral Tissue Engineering

Smirani R, Rémy M, Devillard R, Naveau A

BACKGROUND: Cocultures of human gingival fibrobasts (hGF) and endothelial cells could enhance regeneration and repair models as well as improve vascularization limitations in tissue engineering. The aim of this study...
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The effect of fibroblast growth factor receptor inhibition on resistance exercise training-induced adaptation of bone and muscle quality in mice

Cho S, Lee H, Lee HY, Kim SJ, Song W

Aging in mammals, including humans, is accompanied by loss of bone and muscular function and mass, characterized by osteoporosis and sarcopenia. Although resistance exercise training (RET) is considered an effective intervention,...
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The Role of Adiponectin in the Skin

Oh J, Lee Y, Oh SW, Li T, Shin J, Park SH, Lee J

Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely...
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Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts

Suh J, Kim DH, Kim SJ, Cho NC, Lee YH, Jang JH, Surh YJ

Cancer-associated fibroblasts (CAFs) represent a major component of the tumor microenvironment and interplay with cancer cells by secreting cytokines, growth factors and extracellular matrix proteins. When estrogen receptor-negative breast cancer...
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Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

Chang E, Chang JS, Kong ID, Baik SK, Kim MY, Park KS

Nonalcoholic fatty liver disease (NAFLD) is accompanied by a complex and multifactorial pathogenesis with sequential progressions from inflammation to fibrosis and then to cancer. This heterogeneity interferes with the development...
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Cathepsin D Expression in Oral Squamous Cell Carcinoma and Cancer-Associated Fibroblasts: A Preliminary Study

Kim D, Moon S

Background: Cancer-associated fibroblasts (CAFs) are abundant in tumor microenvironments and interact with cancer cells to promote tumor proliferation in oral squamous cell carcinoma (OSCC). Cathepsin D (CTSD) is a soluble...
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Association of fibroblast growth factor 21 with metabolic syndrome and endothelial function in children: a prospective cross-sectional study on novel biomarkers

Domouzoglou EM, Vlahos AP, Cholevas VK, Papafaklis MI, Chaliasos N, Siomou E, Michalis LK, Tsatsoulis A, Naka KK

Purpose: Metabolic and cardiovascular disease prevention starting in childhood is critical for reducing morbidity later in life. In the present study, the association of novel biomarkers with metabolic syndrome (MS)...
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68Ga-FAPI-46 PET/MR Detects Recurrent Cholangiocarcinoma and Intraductal Papillary Mucinous Neoplasm in a Patient Showing Increasing CEA with Negative 18F-FDG PET/CT and Conventional CT

Siripongsatian D, Promteangtrong C, Kunawudhi A, Kiatkittikul P, Chotipanich C

A patient with intrahepatic cholangiocarcinoma who underwent hepatic resection with completed neoadjuvant chemotherapy presented with increased CEA levels. Previous whole abdominal and chest CT scan revealed no evidence of local...
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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method

Mudalal M, Wang Z, Mustafa S, Liu Y, Wang Y, Yu J, Wang S, Sun X, Zhou Y

Background: An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use of the leukocyte-platelet rich fibrin (L-PRF) in tissue engineering...
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Galectin-3 Derived from HucMSC Exosomes Promoted Myocardial Fibroblast-to-Myofibroblast Differentiation Associated with β-catenin Upregulation

Guo Q, Zhao Y, Li J, Huang C, Wang H, Zhao X, Wang M, Zhu W

Background and Objectives: Galectin-3 promotes fibroblast-to-myofibroblast differentiation and facilitates injury repair. Previous studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) promote the differentiation of...
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Anti-inflammatory effect of non-thermal atmospheric pressure plasma for periodontitis treatment: in vitro pilot study

Park Yl, Kim HJ, Lee JY, Jeong SH, Kwon EY, Joo JY

Purpose: The purpose of this study was to evaluate the anti-inflammatory effects of non-thermal atmospheric pressure plasma (NTP) on human gingival fibroblasts (HGFs) for clinical application of periodontal treatment. Materials...
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Improved Differentiation Ability and Therapeutic Effect of miR-23a-3p Expressing Bone Marrow-Derived Mesenchymal Stem Cells in Mice Model with Acute Lung Injury

Zhang P, Liu L, Yao L, Song X

Background and Objectives: Implantation of bone marrow-derived mesenchymal stem cells (BMSCs) has been recognized as an effective therapy for attenuating acute lung injury (ALI). This study aims to discover microRNA...
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Emerging agents for the treatment of metastatic urothelial cancer

Kwon WA, Seo HK

Over the past few decades, platinum-based combination chemotherapy (PBCC) has been the preferred initial therapy for metastatic urothelial cancer (mUC). However, despite a response rate of approximately 50%, a small...
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Change of Extracellular Matrix of Human Vocal Fold Fibroblasts by Vibratory Stimulation

Kim JM, Shin SC, Kwon HK, Cheon YI, Ro JH, Lee BJ

Background and Objectives During speech, the vocal folds oscillate at frequencies ranging from 100–200 Hz with amplitudes of a few millimeters. Mechanical stimulation is an essential factor which affects metabolism...
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Cutis Verticis Gyrata and Acanthosis Nigricans: Just a Coincidence? – A Case Report

Han HS, Park JW, Park KY, Shim JH, Seo SJ

  • KMID: 2513446
  • Korean J Dermatol.
  • 2021 Feb;59(2):153-156.
Cutis verticis gyrata (CVG) is a rare scalp condition that presents as convoluted folds and furrows, which resemble the cerebral cortex. Although the pathogenesis is not fully elucidated, recent investigations...
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Effects of Glucagon-Like Peptide-1 Analogue and Fibroblast Growth Factor 21 Combination on the Atherosclerosis-Related Process in a Type 2 Diabetes Mouse Model

Kim JH, Lee GY, Maeng HJ, Kim H, Bae JH, Kim KM, Lim S

Background: Glucagon-like peptide-1 (GLP-1) analogues regulate glucose homeostasis and have anti-inflammatory properties, but cause gastrointestinal side effects. The fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and...
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The proper concentrations of dextrose and lidocaine in regenerative injection therapy: in vitro study

Woo MS, Park J, Ok SH, Park M, Sohn JT, Cho MS, Shin IW, Kim YA

Background: Prolotherapy is a proliferation therapy as an alternative medicine. A combination of dextrose solution and lidocaine is usually used in prolotherapy. The concentrations of dextrose and lidocaine used in...
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Studies on inhibition of gingival fibroblast proliferation by nicotine concentration

Han KU, Lee CH, Lee JH, Jeon YM, Yoo HJ

Objectives: To investigate the effect of nicotine on the healing of an oral cavity wound, high and low concentrations of nicotine were administered on human gingival fibroblasts. Methods: Nicotine at concentrations...
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