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Occupational Risk Factors for Prostate Cancer: A Meta-analysis

Krstev S, Knutsson A

Prostate cancer is the second most common cancer in men worldwide. There are many occupational factors that have been suggested to cause prostate cancer. Our aim was to evaluate the...
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HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs

Park HJ, Kim YJ, Kim DH, Kim J, Park KH, Park JW, Lee JH

PURPOSE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very serious forms of drug-induced cutaneous adverse reaction. SJS/TEN induced by certain drug is well known to be associated with...
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Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report

Im SG, Yoo SH, Park YM, Lee SJ, Jang SK, Jeon DO, Cho HJ, Oh MJ

Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs....
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Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella

Zhou BH, Liu LL, Liu J, Yuan FW, Tian EJ, Wang HW

The effects of diclazuril on the bursa of Fabricius (BF) structure and secretory IgA (SIgA) expression in chickens infected with Eimeria tenella were examined. The morphology of the BF was...
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Evidence-Based Korean Pharmacological Treatment Guideline for Depression, Revised Edition (III) : Dose Increment, Switching, Combination, and Augmentation Strategy in Antidepressant Therapy

Han KM, Park SC, Won ES, Sung SH, Lee H, Koo JW, Lee K, Lee HY, Paik JW, Jeon HJ, Lee MS, Shim SH, Ko YH, Lee KJ, Han C, Ham BJ, Choi J, Hwang TY, Oh KS, Hahn SW, Park YC, Lee MS

  • KMID: 2343634
  • J Korean Neuropsychiatr Assoc.
  • 2013 Sep;52(5):386-401.
OBJECTIVES: The aim of this study was to demonstrate the recommendations for antidepressant treatment strategy of dose increment, switching, combination, and augmentation therapy derived from Evidence-Based Korean Pharmacological Treatment Guideline...
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Synergistic effect of melamine in combination with cyanuric acid on urinary tract toxicity in rats

Lee IC, Kim SH, Baek HS, Kang SS, Kim JC

  • KMID: 2055100
  • J Biomed Res.
  • 2013 Sep;14(3):145-153.
The present study investigated the urinary tract toxicity of melamine alone or in combination with cyanuric acid in rats. Male rats were orally administered melamine alone (800 mg/kg) or melamine...
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Psychopharmacotherapy for Pregnant Women

Jeong JH, Suh HS, Lim W, Lee SY

  • KMID: 2287502
  • Korean J Psychopharmacol.
  • 2013 Jul;24(3):102-114.
Authors reviewed the risk of psychopharmacotherapies during pregnancy. Psychopharmaotherapy in pregnants should be determined by considering the risk of disease recurrence in the mother and the impacts on the fetus....
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Treatment Strategy for Non-Responders to PDE5 Inhibitors

Park NC, Kim TN, Park HJ

  • KMID: 2320852
  • World J Mens Health.
  • 2013 Apr;31(1):31-35.
Currently, phosphodiesterase type 5 (PDE5) inhibitors are the initial treatment option for erectile dysfunction. The reported efficacy of PDE5 inhibitors is about 70%, although it is significantly lower in difficult-to-treat...
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Intrathecal Lamotrigine Attenuates Mechanical Allodynia and Suppresses Microglial and Astrocytic Activation in a Rat Model of Spinal Nerve Ligation

Choi YS, Jun IG, Kim SH, Park JY

PURPOSE: Lamotrigine, a novel anticonvulsant, is a sodium channel blocker that is efficacious in certain forms of neuropathic pain. Recently, microglial and astrocytic activation has been implicated in the development...
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Intrathecal Lamotrigine Attenuates Antinociceptive Morphine Tolerance and Suppresses Spinal Glial Cell Activation in Morphine-Tolerant Rats

Jun IG, Kim SH, Yoon YI, Park JY

Glial cells play a critical role in morphine tolerance, resulting from repeated administration of morphine. Both the development and the expression of tolerance are suppressed by the analgesic lamotrigine. This...
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Rash in Psychiatric and Nonpsychiatric Adolescent Patients Receiving Lamotrigine in Korea: A Retrospective Cohort Study

Tak HJ, Ahn JH, Kim KW, Kim YN, Choi SW, Lee KY, Park EJ, Bhang SY

  • KMID: 2316179
  • Psychiatry Investig.
  • 2012 Jun;9(2):174-179.
OBJECTIVE: Lamotrigine is a widely used medication for psychiatric disorders and epilepsy, but the adverse effects of this drug in adolescent Korean patients have not yet been investigated. In the...
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The pharmacological management of neuropathic pain

Ko Y, Kim YH

Neuropathic pain has recently been defined as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system". Neuropathic pain is a debilitating chronic condition that...
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Low-dose, Once-a-day Treatment of Topiramate in Benign Childhood Epilepsy with Centrotemporal Spikes

Choi YE, Jang HI, Bae SY, Son YJ, Lee YJ, Kim YO, Woo YJ

  • KMID: 1441220
  • J Korean Child Neurol Soc.
  • 2012 Jun;20(2):71-79.
PURPOSE: Benign childhood epilepsy with centrotemporal spikes (BECTS) is known to have a good prognosis, and is easily controlled with antiepileptic drugs. In this study, we evaluate the efficacy of...
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The Clinical Analysis of Paroxysmal Kinesigenic Dyskinesia

Suh J, Moon HH, Kwon S

  • KMID: 1441215
  • J Korean Child Neurol Soc.
  • 2012 Jun;20(2):57-63.
PURPOSE: Paroxysmal kinesigenic dyskinesia (PKD) is one of the movement disorders in which dyskinesia occurs in a part of the body by a sudden movement after a rest under a...
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Epilepsy in Korean patients with Angelman syndrome

Park SH, Yoon JR, Kim HD, Lee JS, Lee YM, Kang HC

PURPOSE: The aim of this study was to investigate the natural history of epilepsy and response to anti-epileptic drug treatment in patients with Angelman syndrome (AS) in Korea. METHODS: We retrospectively...
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Target Therapy for Hepatocellular Carcinoma

Yoon SK

Hepatocellular carcinoma (HCC) is a highly malignant tumor that has limited treatment options in its advanced state. The efficacy of current anti-cancer chemotherapy in advanced HCC has not been satisfactory,...
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Tolerability and Pharmacokinetics Following a Single Dose of Vardenafil in Healthy Korean Volunteers

Kim S, Lee S, Lim KS, Lim HS, Shin SG, Jang IJ, Yu KS

  • KMID: 2334532
  • J Korean Soc Clin Pharmacol Ther.
  • 2012 Dec;20(2):125-134.
BACKGROUND: Vardenafil is a phosphodiesterase type 5 inhibitor, used in erectile dysfunction. This study aimed to evaluate the pharmacokinetics and tolerability of vardenafil following a single oral administration in healthy...
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Examination of the Effects of Vardenafil on Esophageal Function Using Multichannel Intraluminal Impedance and Manometry

Lee TH, Lee JS, Hong SJ, Jeon SR, Kim WJ, Kim HG, Cho JY, Kim JO

  • KMID: 2325949
  • J Neurogastroenterol Motil.
  • 2012 Oct;18(4):399-405.
BACKGROUND/AIMS: To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS: Sixteen healthy volunteers...
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Changes of Medication Usage in Inpatients of Major Depressive Disorder: One University Hospital among Year 2001, 2006 and 2010

Song MK, Woo YS, Jun TY, Kim KS, Bahk WM

  • KMID: 2287466
  • Korean J Psychopharmacol.
  • 2012 Oct;23(4):166-175.
OBJECTIVE: Prescription patterns have changed rapidly due to development of new drugs, results of new researches, and increment of clinician's experience. The goal of this study was to examine and...
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Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study

Lee SK, Kim JH, Kim JS, Jang Y, Kim J, Park YH, Chun KJ, Lee MY

BACKGROUND: The activation of guanine nucleotide binding protein-coupled receptors, such as adenosine receptor (ADR) and opioid receptor (OPR), protects the heart against ischemia and reperfusion injury. We hypothesized that ADR...
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