Clin Mol Hepatol.  2015 Jun;21(2):180-182. 10.3350/cmh.2015.21.2.180.

Liver dysfunction induced by systemic hypersensitivity reaction to lamotrigine: case report

• Im SG
• Yoo SH
• Park YM
• Lee SJ
• Jang SK
• Jeon DO
• Cho HJ
• Oh MJ

• KMID: 2164369
• DOI: http://doi.org/10.3350/cmh.2015.21.2.180

Abstract

Lamotrigine is an anticonvulsant drug used to treat partial and generalized seizure disorders. Hypersensitivity to lamotrigine usually causes mild symptoms such as fever, rash, and slight invasion of internal organs. However, a 33-year-old male patient who was admitted with Stevens-Johnson syndrome after taking lamotrigine for 15 days experienced hepatic failure and died 5 days after admission. This case demonstrates the importance of realizing that lamotrigine can lead to fatal hepatic failure, and that tests for the normal liver function should be performed when administering lamotrigine.

Keyword

Lamotrigine; Hypersensitivity; Hepatotoxicity

MeSH Terms

Adult
Alanine Transaminase/blood
Anticonvulsants/*adverse effects/therapeutic use
Aspartate Aminotransferases/blood
Drug Hypersensitivity/complications/*diagnosis
Humans
Liver/enzymology/metabolism
Liver Failure/*etiology
Male
Stevens-Johnson Syndrome/diagnosis/drug therapy
Triazines/*adverse effects/therapeutic use
Alanine Transaminase
Anticonvulsants
Aspartate Aminotransferases
Triazines