Korean J Pediatr.  2009 Mar;52(3):389-391. 10.3345/kjp.2009.52.3.389.

A case of antiepileptic drug hypersensitivity syndrome by lamotrigine mimicking infectious mononucleosis and atypical Kawasaki disease

• Yoo SJ
• Park IS
• Suh ES

• KMID: 2281121
• DOI: http://doi.org/10.3345/kjp.2009.52.3.389

Abstract

Antiepileptic drug hypersensitivity syndrome (AHS), a delayed immunological reaction, is a relatively rare side effect of antiepileptic drugs and is usually overlooked. An array of symptoms can occur one to eight weeks after treatment with an antiepileptic drug. Symptoms may be as simple as a fever, skin rash, or lymphadenopathy, but may eventually involve internal organs and cause fatal outcomes. Additionally, because the symptoms resemble the features of various arrays of diseases and the reported mortality rate is approximately 10%, the importance of early diagnosis and ability to differentiate AHS from other diseases cannot be overemphasized. We report a case of a 14-year-old girl with AHS caused by lamotrigine, which mimicked atypical Kawasaki disease and infectious mononucleosis.

Keyword

Lamotrigine; Antiepileptic hypersensitivity syndrome

MeSH Terms

Adolescent
Anticonvulsants
Drug Hypersensitivity
Early Diagnosis
Exanthema
Fatal Outcome
Fever
Humans
Infectious Mononucleosis
Lymphatic Diseases
Mucocutaneous Lymph Node Syndrome
Triazines
Anticonvulsants
Triazines