J Korean Soc Pediatr Nephrol.
2012 Apr;16(1):1-8.
Circadian Rhythm of ADH, Hypercalciuria, and Solute Diuresis as Pathogenesis of Enuresis
- Affiliations
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- 1Department of Pediatrics, Seoul National University Children's Hospital, Korea. kanghg@snu.ac.kr
Abstract
- Nocturnal polyuria is one of the main pathogenic mechanisms of enuresis. Disturbance of circadian rhythm of antidiuretic hormone (ADH or AVP), hypercalciuria, and/or solute diuresis are considered to cause nocturnal polyuria, which in turn causes enuresis in patients with relatively small bladder capacity and high threshold for awakening. Evaluation of these factors would guide the therapeutic approach for enuresis.
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