J Korean Soc Pediatr Nephrol.  2011 Oct;15(2):146-153.

Urinary Calcium Excretion in Children with Primary Monosymptomatic Nocturnal Enuresis

• Chung WY
• Cho MH
• Park YH
• The Korean Children's Continence and Enuresis Society

Abstract

PURPOSE
Hypercalciuria has been suggested to be involved in the pathogenesis of nocturnal enuresis associated with polyuria. We have measured the amount of calcium excretion in the urine from children with monosymptomatic nocturnal enuresis and studied the association with enuresis.
METHODS
Thirty-six children (20 males and 16 females, age 5 to 15.6 years) presenting with monosymptomatic nocturnal enuresis were recruited for this study.
RESULTS
Among 36 patients, 6 patients had hypercalciuria, providing a 16.7% frequency. The mean Ca/Cr ratio of hypercalciuria group showed 0.23+/-0.10 on daytime, and 0.33+/-0.10 on nighttime showing higher values in nighttime, but it was not statistically significant. Average 24 hour calcium excretion was 8.95 mg/kg. Night/day time urine volume ratio in hypercalciuria group was 0.87+/-0.20, and that in normocalciuria group was 0.81+/-0.33, also showing no difference. Daytime Ca/Cr ratio and nighttime Ca/Cr ratio from all enuresis patients showed a significant correlation (P=0.0001). However, Ca/Cr ratio between daytime and nighttime urine volume had no significant correlation, respectively (daytime P=0.08; nighttime P=0.07). Also, daytime and nighttime Na concentration, urea concentration, and osmolality also had no significant correlation with urine Ca/Cr ratio, respectively.
CONCLUSION
Hypercalciuria shown in some of enuresis patients is not directly caused by primary monosymptomatic nocturnal enuresis.

Keyword

Children; Primary monosymptomatic nocturnal enuresis; Hypercalciuria

MeSH Terms

Calcium
Child
Enuresis
Female
Humans
Hypercalciuria
Male
Nocturnal Enuresis
Osmolar Concentration
Polyuria
Urea
Calcium
Urea