J Korean Med Assoc.  2017 Oct;60(10):796-799. 10.5124/jkma.2017.60.10.796.

Pharmacological therapy of nocturnal enuresis

  • 1Department of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, Korea.
  • 2Department of Pediatrics, Pusan National University Children's Hospital, Yangsan, Korea. pedksh@gmail.com


Nocturnal enuresis is a common problem of children during sleeping at preschool or school age. It may affect negatively the psychosocial development of children. Children with enuresis may have lower self-esteem and lower quality of life. There are three main factors of the pathophysiology of enuresis: high nocturnal urine production, nocturnal low bladder capacity or increased detrusor muscle activity, and arousal disorder. As pharmacological therapy for nocturnal enuresis, several medications including desmopressin, anticholinergics, imipramine have been used for a long time. As first-line therapy, desmopressin combined with anticholinergics has good response in primary monosymptomatic nocturnal enuresis. Because imipramine has serious and lethal cardiotoxic effect with overdosage, imipramine should be prescribed after EKG to rule out the conduction problem of heart.


Nocturnal enuresis; Desmopressin; Anticholinergics; Imipramine

MeSH Terms

Cholinergic Antagonists
Deamino Arginine Vasopressin
Nocturnal Enuresis*
Quality of Life
Urinary Bladder
Cholinergic Antagonists
Deamino Arginine Vasopressin

Cited by  1 articles

Current management scheme of nocturnal enuresis
Kwanjin Park
J Korean Med Assoc. 2017;60(10):790-791.    doi: 10.5124/jkma.2017.60.10.790.


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