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Development of objective indicators for quantitative analysis of sodium intake: the sodium to potassium ratio of second-void urine is correlated with 24-hour urinary sodium excretion

Kim JG, Han SW, Yi JH, Park HC, Han SY

BACKGROUND/OBJECTIVES: To date, sodium intake has been evaluated based on spot urine instead of 24-hour (hr) urine collection. Nevertheless, the optimal method for assessing daily sodium intake remains unclear. SUBJECTS/METHODS: Fifteen...
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Comparison between Tear Film Osmolar Cocentration and Other Tear Film Function Parameters in Patients with Diabetes Mellitus

Derakhshan A, Abrishami , Khajedaluee M, Omidtabrizi A, Moghaddam

PURPOSE: To evaluate tear film function in patients with diabetes mellitus (DM) using tear film osmolarity (TFO) measurements compared to other tear film function tests. METHODS: DM patients without any history...
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A Case of Adipsic Hypernatremia in a Patient with Panhypopituitarism Treated with Growth Hormone Replacement

Mhun EH, Lee JH, Lee DH

Adipsic hypernatremia is a rare disease where patients do not feel thirst even in the increased serum osmotic pressure and results in electrolyte imbalance, severely increased osmotic pressure and neurologic...
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New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus

Jung HJ, Kwon TH

The kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis....
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Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRAC(swell)) in the Brain

Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ

In the brain, a reduction in extracellular osmolality causes water-influx and swelling, which subsequently triggers Cl⁻- and osmolytes-efflux via volume-regulated anion channel (VRAC). Although LRRC8 family has been recently proposed...
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Factors Associated with Development of Early Symptoms of Phlebitis in Hospitalized Patients in General Wards: A Retrospective Study

Lee Y, Lee E

PURPOSE: The objective of this study was to identify the risk factors for early symptoms of phlebitis with peripheral intravenous catheters. METHODS: This study involved 226 patients who were admitted to...
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Discrepancies and Validation of Ethanol Level Determination with Osmolar Gap Formula in Patients with Suspected Acute Poisoning

Jung H, Lee MJ, Cho JW, Ahn JY, Kim C

PURPOSE: Osmolar gap (OG) has been used for decades to screen for toxic alcohol levels. However, its reliability may vary due to several reasons. We validated the estimated ethanol concentration...
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Clinical Symptoms and Signs of Dry Eye Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Beak JU, Ha MJ, Yi R, Yoo YS, Kim HS, Na KS

PURPOSE: To identify the symptoms and signs of patients with dry eye disease (DED) after allogenic hematopoietic stem cell transplantation (HSCT) and analyze the correlations between these signs and symptoms. METHODS:...
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Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis

Kim CH, Seong S, Kim JK, Choi JH, Choe CM, Choi TH, Kim S

PURPOSE: To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK). METHODS: This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK....
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Evaluation of the Protective Effect of an Ophthalmic Viscosurgical Device on the Ocular Surface in Dry Eye Patients during Cataract Surgery

Yoon DY, Kim JH, Jeon HS, Jeon HE, Han SB, Hyon JY

PURPOSE: To evaluate the protective effect of applying an ophthalmic viscosurgical device (OVD) to the ocular surface during cataract surgery and its ability to prevent dry eye syndrome. METHODS: Twenty-four patients...
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Annual Report on the External Quality Assessment Scheme for General Chemistry in Korea (2017)

Lee YW

In 2017, the clinical chemistry proficiency testing program consisted of 24 programs with the addition of the urine chemistry program in the Korean Association of External Quality Assessment Service. The...
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Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6

Kim H, Choi S, Park E, Yoon E, Min Y, Lampotang

OBJECTIVE: Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS...
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A Rare Case of Hyponatremia Caused by Reset Osmostat in a Neonate with Cleft Lip, Cleft Palate, and Imperforate Anus

Ahn JG, Lee JE, Chung WY, Koo SH, Shin J, Jeon GW

Hyponatremia is defined as a plasma sodium concentration of < 135 mEq/L. It is a common electrolyte imbalance in newborns. We report the case of a term neonate with cleft...
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Lid Wiper Epitheliopathy in Patients with Dry Eye Refractory to Conventional Medical Treatment

Huh J, Woo IH, Eom Y, Kang SY, Kim HM, Song JS

PURPOSE: We evaluated the effects of lid wiper epitheliopathy on the clinical manifestations of dry eye in patients refractory to conventional medical treatment. METHODS: Forty-six patients (46 eyes) completed the subjective...
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Diagnosis and treatment of dry eye syndrome

Kim EC

Dry eye syndrome is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film, and accompanied by ocular symptoms. Tear film instability and...
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Comparison of Osmolarity of Various Artificial Tears Products Commercially Available in South Korea

Woo IH, Hong JG, Huh JA, Eom Y, Kim HM, Song JS

PURPOSE: To compare the osmolarity of various artificial tear products commercially available in the Republic of Korea. METHODS: The osmolarity of the artificial tears was analyzed using TearLab® and Multi-Osmette™. We...
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Long-term Tolvaptan Treatment of Autosomal Dominant Polycystic Kidney Disease in Korea

Kim HY, Lee SJ, Kim BK, Kim M, Bae EH, Ma SK, Kim SW

A 22-year-old male patient was diagnosed with autosomal dominant polycystic kidney disease (ADPKD). He received conservative treatment with an angiotensin-converting enzyme inhibitor. Two years later, oral therapy, consisting of 60...
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Central Diabetes Insipidus Linked to Rathke's Cleft Cyst, Polyuria in a 17-year-old Girl

Kim HY, Lee SJ, Bae EH, Ma SK, Kim SW

A 17-year-old girl presented with polyuria (7 L/day) and polydipsia for one year. Initial urine osmolality was 113mOsm/kg Hâ‚‚O. Following 6 h of fluid restriction, serum plasma osmolality reached 300mOsm/kg...
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Correlations between Tear Osmolarity and Ocular and Systemic Parameters in Primary Sjögren's Syndrome

Yoon DY, Kim JH, Jeon HS, Wee WR, Hyon JY

PURPOSE: To investigate the relationships between tear osmolarity and various parameters for ocular and systemic disease in primary Sjögren's syndrome. METHODS: The medical records of 53 patients with primary Sjögren's syndrome...
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Clinical Significance of Tear Film Osmolarity for Non-Sjögren Dry Eye Diagnosis

Yun JM, Yim HB, Kim HS, Na KS

PURPOSE: To evaluate the diagnostic value of tear film osmolarity for non-Sjogren dry eye syndrome through measuring the correlation between tear osmolarity and several conventional dry eye parameters. METHODS: In this...
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