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Signaling Role of Adipocyte Leptin in Prostate Cell Proliferation Induced by Trichomonas vaginalis

Kim JH, Han IH, Shin SJ, Park SY, Chung HY, Ryu JS

Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate...
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The Relationship of Leptin (+19) AG, Leptin (2548) GA, and Leptin Receptor Gln223Arg Gene Polymorphisms with Obesity and Metabolic Syndrome in Obese Children and Adolescents

Bilge S, Yılmaz R, Karaslan E, Özer S, Ateş , Ensari E, Demir O

Purpose: Obesity is defined as the abnormal or excessive accumulation of fat over acceptable limits. Leptin is a metabolic hormone present in the circulation in amounts proportional to fat mass....
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The Role of Leptin in the Association between Obesity and Psoriasis

Hwang J, Yoo JA, Yoon H, Han T, Yoon J, An S, Cho JY, Lee J

Adipose tissue secretes many adipokines which contribute to various metabolic processes, such as blood pressure, glucose homeostasis, inflammation and angiogenesis. The biology of adipose tissue in an obese individual is...
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Elevated Serum Leptin Receptor and Insulin-like Growth Factor-1 Levels and High Levels of Leptin Receptor Expression in Acanthosis Nigricans Patients: Serologic and Histopathologic Analyses

Kim WO, Kim HW, Joe HJ, Ryoo YW, Jung HR, Kim SA

  • KMID: 2506584
  • Korean J Dermatol.
  • 2020 Sep;58(8):530-536.
Background: Acanthosis nigricans is characterized by a velvety thickening of the epidermis accompanied by different degrees of hyperpigmentation, and known to be linked to obesity and insulin resistance. Objective: We aimed...
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Effect of Weight Reduction on Treatment Outcomes for Patients with Atopic Dermatitis

Jung MJ, Kim HR, Kang SY, Kim HO, Chung BY, Park CW

Background: Several epidemiological studies have shownthat the atopic tendency increases in the obese population. Objective: The aim of this study was to confirm the effect ofweight reduction on improvement of atopic...
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Serum adipocytokines and adiposity as predictive indices of preeclampsia

Bawah AT, Yeboah FA, Nanga S, Alidu H, Ngala RA

Background This study was aimed at determining the levels of serum adiponectin, leptin, resistin, visfatin and lipids during the first trimester in pregnant women and to evaluate the relationship between these...
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Determinants of Circulating Soluble Leptin Receptor and Free Leptin Index in Indonesian Pre-Pubertal Obese Male Children: A Preliminary Cross-Sectional Study

Hendarto A, Nagrani DG, Meiliana A, Sastroasmoro S, Sjarif DR

PURPOSE: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. METHODS: We conducted a...
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Leptin as a Key between Obesity and Cardiovascular Disease

Kang KW, Ok M, Lee SK

Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly...
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Blood level of adipokines and nutritional status variables in adolescent pregnancy

Fernandes MD, Daher S, de Sousa LM, Baratto I, Lobo TF, Araujo Júnior E, Guazzelli CAF

Objective To evaluate the serum levels of adiponectin and leptin and their relationship with nutritional variables during pregnancy in adolescents. Methods This prospective cohort study evaluated eutrophic pregnant adolescents (body mass...
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Effects of Microbiota on the Treatment of Obesity with the Natural Product Celastrol in Rats

Hu W, Wang L, Du G, Guan Q, Dong T, Song L, Xia Y, Wang X

Background Obesity has become one of the most serious issues threatening the health of humankind, and we conducted this study to examine whether and how celastrol protects against obesity. Methods We fed male...
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Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase L, Doerr JP, Feige B, Rechenbach M, Fiebich BL, Riemann D, Nissen C, Voderholzer U

OBJECTIVE: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in...
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Sleep and Obesity

Ding C, Lim LL, Xu L, Kong AP

Rising global prevalence and incidence of obesity lead to increased cardiovascular-renal complications and cancers. Epidemiological studies reported a worldwide trend towards suboptimal sleep duration and poor sleep quality in parallel...
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Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

Boutari C, Perakakis , Mantzoros

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in...
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The association of leptin with severity of non-alcoholic fatty liver disease: A population-based study

Rotundo L, Persaud A, Feurdean M, Ahlawat S, Kim HS

BACKGROUND/AIMS: Leptin is associated with metabolic disorders, which predispose one to non-alcoholic fatty liver disease (NAFLD). The role of leptin in NAFLD pathogenesis is not fully understood. We aim to...
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Effects of Maternal and Post-Weaning High-Fat Diet on Leptin Resistance and Hypothalamic Appetite Genes in Sprague Dawley Rat Offspring

Choi JS

The defective satiation signaling may contribute to the etiology of obesity. We investigated how dietary modification during maternal (pregnancy and lactation) and post-weaning affects obesity, insulin resistance (IR) and hypothalamic...
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Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice

Ryu SY, Choi YJ, Park SY, Kim JY, Kim YD, Kim YW

PURPOSE: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in...
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Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

Mexitalia , Dewi YO, Pramono A, Anam MS

PURPOSE: Tuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an...
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Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study

Kang DR, Yadav D, Koh SB, Kim JY, Ahn SV

PURPOSE: The ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on...
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Role of the Cytokine-like Hormone Leptin in Muscle-bone Crosstalk with Aging

Hamrick MW

The cytokine-like hormone leptin is a classic adipokine that is secreted by adipocytes, increases with weight gain, and decreases with weight loss. Additional studies have, however, shown that leptin is...
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p53 signaling is involved in leptin-induced growth of hepatic and breast cancer cells

Shrestha M, Park PH

Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized...
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