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The Effect of Breastfeeding on Prevention of Maternal Hypertension: Systematic Review

Jeon H, Joo SH, Choi A, Han JY, Jeong ES, Shin HJ, Kim JY

PURPOSE: The purpose of this study is to clarify the relevance of breastfeeding and its preventive effect on maternal hypertension as well as to evaluate the theoretical mechanism behind of...
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Effect of Ghrelin on Memory Impairment in a Rat Model of Vascular Dementia

Park JM, Kim YJ

PURPOSE: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. METHODS: Randomized controlled...
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Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment

Kim BJ, Kuo B

  • KMID: 2433495
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):27-35.
  • doi: 10.5056/jnm18162
Gastroparesis and functional dyspepsia are 2 of the most common gastric neuromuscular disorders. These disorders are usually confused, having both similarities and differences. The pathophysiology of these disorders involves abnormal...
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Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants

Frase L, Doerr JP, Feige B, Rechenbach M, Fiebich BL, Riemann D, Nissen C, Voderholzer U

OBJECTIVE: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in...
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Sleep and Obesity

Ding C, Lim LL, Xu L, Kong AP

Rising global prevalence and incidence of obesity lead to increased cardiovascular-renal complications and cancers. Epidemiological studies reported a worldwide trend towards suboptimal sleep duration and poor sleep quality in parallel...
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Evaluating the Levels of Nesfatin-1 and Ghrelin Hormones in Patients with Moderate and Severe Major Depressive Disorders

Algul S, Ozcelik O

OBJECTIVE: The goal of this study was to evaluate the importance of nesfatin-1, acylated and des-acylated ghrelin, which are known as energy regulatory hormones, in patients with moderate and severe...
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Combination of Obestatin and Bone Marrow Mesenchymal Stem Cells Prevents Aggravation of Endocrine Pancreatic Damage in Type II Diabetic Rats

Hussien NI, Ebrahim N, Mohammed O, Sabry D

One of the new promising therapies in treatment of diabetes mellitus is mesenchymal stem cells (MSCs) which have an interesting therapeutic potentiality based on their paracrine effect and transdifferentiation potentiality....
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Leu72Met and Other Intronic Polymorphisms in the GHRL and GHSR Genes Are Not Associated with Type 2 Diabetes Mellitus, Insulin Resistance, or Serum Ghrelin Levels in a Saudi Population

Joatar FE, Al Qarni A, Ali ME, Al Masaud , Shire AM, Das N, Gumaa K, Giha HA

BACKGROUND: Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth hormone secretagogue...
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The Relationship between Ghrelin and Copeptin Levels, and Anxiety and Depression Levels in Suicide Attempts

Atescelik , Yilmaz M, Korkmaz S, Goktekin M, Gurger M, Ilhan N

OBJECTIVE: It was aimed to detect acylated ghrelin (AG), unacylated ghrelin (UG) and copeptin levels in patients with suicide attempts and to determine if these biomarkers are risk factors for...
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Metabolic Syndrome is Associated with Lower Plasma Levels of Desacyl Ghrelin and Total Ghrelin in Asymptomatic Middle-aged Korean Men

Cho YH, Lee SY, Jeong DW, Cho AR, Jeon JS, Kim YJ, Lee JG, Yi YH, Tak YJ, Hwang HR, Lee SH, Lee SM

BACKGROUND: Desacyl ghrelin is acylated by ghrelin O-acyltransferase (GOAT) and converted to acyl ghrelin. To date, little is known about the relationship among the levels of these two forms of...
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Association of Plasma Ghrelin Levels with Insulin Resistance in Type 2 Diabetes Mellitus among Saudi Subjects

Al Qarni A, Joatar FE, Das N, Awad M, Eltayeb M, Al-Zubair , Ali ME, Al Masaud , Shire AM, Gumaa K, Giha HA

BACKGROUND: Although the exact mechanism of insulin resistance (IR) has not yet been established, IR is the hallmark characteristic of type 2 diabetes mellitus (T2DM). The aim of this study...
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Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity

Prinz P, Stengel A

  • KMID: 2433519
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):180-196.
  • doi: 10.5056/jnm16194
This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1...
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Future Treatment of Constipation-associated Disorders: Role of Relamorelin and Other Ghrelin Receptor Agonists

Mosińska , Zatorski H, Storr M, Fichna J

  • KMID: 2433518
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):171-179.
  • doi: 10.5056/jnm16183
There is an unmet need for effective pharmacological therapies for constipation, a symptom that significantly deteriorates patients' quality of life and impacts health care. Ghrelin is an endogenous ligand for...
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Meta-analysis of Circulating Adiponectin, Visfatin, and Ghrelin Levels in Patients with Systemic Lupus Erythematosus

Lee YH, Song GG

OBJECTIVE: To evaluate the association between circulating adiponectin, visfatin, and ghrelin levels and systemic lupus erythematosus (SLE). METHODS: We conducted a meta-analysis to compare serum/plasma adiponectin, visfatin, and ghrelin levels in...
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Effect of DA-9701, a Novel Prokinetic Agent, on Post-operative Ileus in Rats

Lee SP, Lee OY, Lee KN, Lee HL, Choi HS, Yoon BC, Jun DW

  • KMID: 2367462
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):109-116.
  • doi: 10.5056/jnm16003
BACKGROUND/AIMS: Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain....
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Current Status of Translational Research on Functional Dyspepsia

Park JH, Kim JW, Park JK, Shin CM, Jung KW

Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite...
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Novel Molecules Regulating Energy Homeostasis: Physiology and Regulation by Macronutrient Intake and Weight Loss

Gavrieli A, Mantzoros

Excess energy intake, without a compensatory increase of energy expenditure, leads to obesity. Several molecules are involved in energy homeostasis regulation and new ones are being discovered constantly. Appetite regulating...
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The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice

Lee JH, Kim TJ, Kim JW, Yoon JS, Kim HS, Lee KM

Thymic atrophy is a complication that results from exposure to many environmental stressors, disease treatments, and microbial challenges. Such acute stress-associated thymic loss can have a dramatic impact on the...
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Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet

Janas RM, Rybak A, Wierzbicka-Rucińska A, Socha P, Śnitko R, Szaflarska-Popławska A, Stolarczyk A, Oralewska , Cytra-Jarocka E, Iwańczak , Grzybowska-Chlebowczyk U, Cichy W, Czaja-Bulsa G, Socha J

BACKGROUND/AIMS: The roles of the many bioactive peptides in the pathogenesis of celiac disease remain unclear. To evaluate the serum concentrations of insulin, ghrelin, adiponectin, leptin, leptin receptor, and lipocalin-2...
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Response: Serum Concentrations of Ghrelin and Leptin according to Thyroid Hormone Condition, and Their Correlations with Insulin Resistance (Endocrinol Metab 2015;30:318-25, Kyu-Jin Kim et al.)

Jung CH

No abstract available.
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