Biomol Ther.  2017 Jul;25(4):345-353. 10.4062/biomolther.2016.126.

Production of Recombinant Anti-Cancer Vaccines in Plants

Affiliations
  • 1Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea. ksko@cau.ac.kr

Abstract

Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.

Keyword

Cancer; Vaccine; Glycosylation; Plant expression system; Subunit vaccine; Recombinant protein

MeSH Terms

Biomass
Bioreactors
Glycosylation
Plants
Recombinant Proteins
Vaccines*
Vaccines, Subunit
Recombinant Proteins
Vaccines
Vaccines, Subunit
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