J Korean Neuropsychiatr Assoc.  2000 Jul;39(4):766-773.

The Change of Cytokines by Risperidone in Patients with Schizophrenia

• Kim DJ
• Kim W
• Yoon SJ
• Go HJ
• Choi BM
• Jun TY

Abstract

OBJECT: This study was carried out to evaluate immunologic difference between baseline and after 4 weeks drug treatment with atypical antipsychotics (rispreidone) by measurement of serum concentration of 6 cytokines.
METHODS
The subjets were composed of 25 patients who are admitted at Dajeon St's Marys hospital of psychiatry department and diagnosed as schizophrenia by DSM-IV diagnositc criteria. We measured serum IL-1beta, IL-2, IL-6, IL-12, INF-gamma, TNF-alpha concenatrations by quantitative ELISA method using ELISA kit (Endogen Inc., Woburn, MA, USA).The two psyciatrists performed PANSS examination between baseline and after 4 weeks risperidone treatments.
RESULTS
The serum level of IL-12 was increased significantly after medication of 4 weeks and the serum concentration of IFN-gamma showed the tendency of decreasement but not significant. The serum level of the other cytokines showed no significant change.
CONCLUSIONS
We spectulate that the increasement of IL-12 may contribute to role of activation of immune response by treatment of antipsychotic medication (risperidone). This study is first trial of IL-12 study in neuropsychiatric field and IL-12 which play important role of immune response becomes interesting subjects in immune research.

Keyword

Schizophrenia; Interleukin; Risperidone

MeSH Terms

Antipsychotic Agents
Cytokines*
Diagnostic and Statistical Manual of Mental Disorders
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-12
Interleukin-2
Interleukin-6
Interleukins
Risperidone*
Schizophrenia*
Tumor Necrosis Factor-alpha
Antipsychotic Agents
Cytokines
Interleukin-12
Interleukin-2
Interleukin-6
Interleukins
Risperidone
Tumor Necrosis Factor-alpha