J Korean Neuropsychiatr Assoc.
1999 Nov;38(6):1522-1526.
A Case of Risperidone-Induced Hepatotoxicity
- Affiliations
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- 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
- A few cases describing hepatotoxicity associated with administration of risperidone have been repo-rted. In most cases, the abnormal liver function was normalized without specific treatment. Therefore, it has not been strictly recommended for monitoring liver function during a treatment with risperidone. We experienced a case of risperidone-induced hepatotoxicity which was not normalized spontaneously in a patient with schizophrenia. The liver enzyme was elevated according to the administration of risperidone continuously, and normalized only after discontinuation of risperidone. Unlike previous reports, the patient had no history of liver disease and demonstrated abnormal liver function from the relatively earlier period of treatment. Therefore, we recommend that it is necessary to be cautious of monitoring liver function during administration of risperidone.
