- Anti-inflammatory and Immunosuppressive Effects of Panax notoginseng
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Cao TQ, Han JH, Lee HS, Ha MT, Woo MH, Min BS
- KMID: 2468065
- Nat Prod Sci.
- 2019 Dec;25(4):317-325.
- doi: 10.20307/nps.2019.25.4.317
Here, we designed to examine the anti-inflammatory effects on RAW264.7 cells and the immunosuppressive effects by evaluating interleukin-2 (IL-2) production in Jurkat T cells using a MeOH extract of Panax... -
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- Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1
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Zhang P, Yu J, Gui Y, Sun C, Han W
- KMID: 2460227
- Yonsei Med J.
- 2019 Nov;60(11):1093-1102.
- doi: 10.3349/ymj.2019.60.11.1093
PURPOSE: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the... -
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- Factors Predicting the Response to Cyclosporin Treatment in Patients With Chronic Spontaneous Urticaria: A Systematic Review
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Kulthanan , Subchookul C, Hunnangkul S, Chularojanamontri L, Tuchinda P
- KMID: 2452762
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):736-755.
- doi: 10.4168/aair.2019.11.5.736
PURPOSE: This study aimed to systemically review literature relating to factors that could potentially predict a favorable response to cyclosporine A (CsA) treatment for chronic spontaneous urticaria (CSU). METHODS: A systematic... -
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- Extrinsic Acquisition of CD80 by Antigen-Specific CD8⺠T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
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Son J, Ha SJ
- KMID: 2455935
- Immune Netw.
- 2019 Aug;19(4):e25.
- doi: 10.4110/in.2019.19.e25
CD80 is mainly expressed on Ag-presenting cells (APCs) as a costimulatory molecule but is also detected on T cells. However, the origin and physiological role of CD80 on CD8⺠T... -
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- A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer
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Chung HW, Kim JJ, Choi JI, Lee HR, Lim JB
- KMID: 2452951
- Yonsei Med J.
- 2019 Aug;60(8):713-719.
- doi: 10.3349/ymj.2019.60.8.713
PURPOSE: We aimed to evaluate the clinical significance of a disintegrin and metalloproteinase 8 (ADAM 8) as a potential blood biomarker for gastric cancer (GC). MATERIALS AND METHODS: Blood ADAM 8... -
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- MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1
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Yang Q, Li J, Hu Y, Tang X, Yu L, Dong L, Chen D
- KMID: 2446954
- Yonsei Med J.
- 2019 Jun;60(6):500-508.
- doi: 10.3349/ymj.2019.60.6.500
PURPOSE: Lung adenocarcinoma (LA) is one of the major types of lung cancer. MicroRNAs (miRNAs) play an essential role in regulating responses of natural killer (NK) cells to cancer malignancy.... -
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- Peripheral Biomarkers for First-Episode Psychosis—Opportunities from the Neuroinflammatory Hypothesis of Schizophrenia
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Trovão N, Prata J, VonDoellinger O, Santos S, Barbosa M, Coelho R
- KMID: 2447256
- Psychiatry Investig.
- 2019 Mar;16(3):177-184.
- doi: 10.30773/pi.2018.12.19.1
OBJECTIVE: Schizophrenia is a disabling disorder of unknown aetiology, lacking definite diagnostic method and cure. A reliable biological marker of schizophrenia is highly demanded, for which traceable immune mediators in... -
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- Recent medical therapy for psoriasis
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Youn SW
- KMID: 2441069
- J Korean Med Assoc.
- 2019 Mar;62(3):176-180.
- doi: 10.5124/jkma.2019.62.3.176
Psoriasis is a chronic inflammatory disease. Medical therapy is the mainstay of the management of psoriasis, and the main target of psoriasis treatment is immunological dysregulation. Cyclosporine and methotrexate, the... -
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- Comparison Between Signature Cytokines of Nasal Tissues in Subtypes of Chronic Rhinosinusitis
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Kim DK, Eun KM, Kim MK, Cho D, Han SA, Han SY, Seo Y, Lee DH, Cho SH, Kim DW
- KMID: 2431852
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):201-211.
- doi: 10.4168/aair.2019.11.2.201
PURPOSE: Endotype in chronic rhinosinusitis (CRS) has been established in the last decade. However, the exact immunologic profile of CRS still has controversy because it has a considerable immunologic heterogeneity.... -
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- N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis
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Kim HR, Kim KW, Kim BM, Lee KA, Lee SH
- KMID: 2452505
- Korean J Intern Med.
- 2019 Jan;34(1):210-219.
- doi: 10.3904/kjim.2016.329
BACKGROUND/AIMS: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA). METHODS: After RA synovial fibroblasts were stimulated... -
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- Mucosal Immunity Related to FOXP3⺠Regulatory T Cells, Th17 Cells and Cytokines in Pediatric Inflammatory Bowel Disease
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Cho J, Kim S, Yang DH, Lee J, Park KW, Go J, Hyun CL, Jee Y, Kang KS
- KMID: 2429597
- J Korean Med Sci.
- 2018 Dec;33(52):e336.
- doi: 10.3346/jkms.2018.33.e336
BACKGROUND: We aimed to investigate mucosal immunity related to forkhead box P3 (FOXP3+) regulatory T (Treg) cells, T helper 17 (Th17) cells and cytokines in pediatric inflammatory bowel disease (IBD). METHODS:... -
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- A Case of Paradoxical Flare of Pustular Psoriasis after Ustekinumab Therapy
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Kang IH, Shin MK, Lee MH, Jeong KH
- KMID: 2436996
- Korean J Dermatol.
- 2018 Nov;56(9):548-551.
Biologics are the most advanced treatment for psoriasis. Ustekinumab, one of the biologics for psoriasis, is a human monoclonal antibody that binds to the p40 subunit of interleukin-12 and interleukin-23.... -
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- The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats
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Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF
- KMID: 2418999
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):493-501.
- doi: 10.4196/kjpp.2018.22.5.493
The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines... -
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- Two-Track Medical Treatment Strategy According to the Clinical Scoring System for Chronic Rhinosinusitis
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Kim DK, Kang SI, Kong IG, Cho YH, Song SK, Hyun SJ, Cho SD, Han SY, Cho SH, Kim DW
- KMID: 2418047
- Allergy Asthma Immunol Res.
- 2018 Sep;10(5):490-502.
- doi: 10.4168/aair.2018.10.5.490
PURPOSE: The previously reported Japanese clinical scoring study (JESREC) suggests that chronic rhinosinusitis (CRS) can be divided into 4 subtypes according to the degree of eosinophilic CRS (ECRS) and offers... -
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- Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy
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Min B, Choi H, Her JH, Jung MY, Kim HJ, Jung MY, Lee EK, Cho SY, Hwang YK, Shin EC
- KMID: 2419776
- Immune Netw.
- 2018 Aug;18(4):e31.
- doi: 10.4110/in.2018.18.e31
Allogeneic natural killer (NK) cell therapy is a potential therapeutic approach for a variety of solid tumors. We established an expansion method for large-scale production of highly purified and functionally... -
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- Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations
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Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK
- KMID: 2419771
- Immune Netw.
- 2018 Aug;18(4):e26.
- doi: 10.4110/in.2018.18.e26
Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²âº-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various... -
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- Genome-Wide Association Studies of Autoimmune Thyroid Diseases, Thyroid Function, and Thyroid Cancer
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Hwangbo Y, Park YJ
- KMID: 2420484
- Endocrinol Metab.
- 2018 Jun;33(2):175-184.
- doi: 10.3803/EnM.2018.33.2.175
Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to have high heritability. Family and twin studies have indicated that genetics plays a major role in the development... -
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- Novel Cell Permeable Peptide Based on Multi Basic Furin-dependent Cleavage Site of Respiratory Syncytial Virus Fusion Protein
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Cho J, Yi H, Lee MS, Lee CH, Kang C, Kim K
- KMID: 2414855
- J Bacteriol Virol.
- 2018 Jun;48(2):49-58.
- doi: 10.4167/jbv.2018.48.2.49
Cell permeable peptide (CPP) is able to transport itself or conjugated molecules such as nucleotides, peptides, and proteins into cells. Since short peptide of human immunodeficiency virus-1 Tat has been... -
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- Serum Cytokine Profile in Patients with Chronic Rhinosinusitis with Nasal Polyposis Infected by Aspergillus flavus
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Rai G, Ansari MA, Dar SA, Datt S, Gupta N, Sharma S, Haque S, Ramachandran VG, Mazumdar A, Rudramurthy S, Chakrabarti A, Das S
- KMID: 2403357
- Ann Lab Med.
- 2018 Mar;38(2):125-131.
- doi: 10.3343/alm.2018.38.2.125
BACKGROUND: Fungi, especially Aspergillus flavus, can cause chronic rhinosinusitis with nasal polyposis and modulate host innate immune components. The objective of this study was to examine the serum levels of... -
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- Expression Patterns of Host Inflammatory Cytokine Genes during Infestation with Haemaphysalis longicornis, a Zoonotic Vector, in Blood Sucking Periods
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Islam MS, You MJ
- KMID: 2408525
- Korean J Parasitol.
- 2018 Feb;56(1):53-59.
- doi: 10.3347/kjp.2018.56.1.53
Tick saliva is critically important for continuous attachment to the host, blood feeding for days, and transmission of tick-borne pathogens. To characterize the patterns of inflammatory cytokine gene expression during... -
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