Korean J Urol.
1996 Dec;37(12):1327-1332.
Effect of Intralesional Interleukin-2 on Murine Bladder Tumor
- Affiliations
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- 1Seoul National University College of Medicine, Seoul, Korea.
Abstract
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PURPOSE: We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor.
MATERIALS AND METHODS
In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation rates and growth of the implanted tumors on C3H/He mice receiving six consecutive injections of various concentrations of interleukin-2.
RESULTS
No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors were similar whether interleukin-2's were injected or not.
CONCLUSION
Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.
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