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Thapsigargin Increases IL-2 Production in T Cells at Nanomolar Concentrations

Kim KH, Kim SH, Jung HH, Moon JH, Jeong SU, Yu K, Lee CK

Thapsigargin (TGN) is a potent and selective inhibitor of sarco-endoplasmic Ca²⁺-ATPase, leading to rapid elevation of cytoplasmic Ca2+ concentration. Previous reports have shown that TGN increases the production of various...
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Neolignan Derivatives from the Flower of Magnolia biondii Pamp. and their Effects on IL-2 expression in T-cells

Nguyen TT, Nguyen TT, Lee HS, Jun CD, Min BS, Kim JA

The isolation of the MeOH extract from the flower bud of Magnolia biondii Pamp. using various column chromatographies and HPLC led to eleven neoglignan derivatives (1 - 11). Their structures...
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Anti-GD2 Monoclonal Antibody (dinutuximab) with GM-CSF, Interleukin 2, and Cis-retinoic Acid for the Treatment of High-risk Neuroblastoma

Jeon IS

Neuroblastoma, one of the most common solid tumors in early childhood, exhibits aberrant cell-surface glycosylation patterns. In neuroblastoma, disialoganglioside (GD2) is expressed homogeneously and abundantly on 100% of neuroblastoma cells....
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The Efficacy and Safety of an Immunosuppressive Regimen Including the Use of Mycophenolate Mofetil and an Interleukin-2 Monoclonal Antibody in Heart Transplant Patients

Ahn JM, Kim JJ, Song MG, Kim HY, Lee CH, Song JK, Park SW, Park SJ, Kim IO

BACKGROUND AND OBJECTIVES: An immunosuppressive regimen including the use of mycophenolate mofetil (MMF) and an interleukin-2 monoclonal antibody (IL2mAb) has shown promise to prevent acute rejection after heart transplantation. There...
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A Case of Steroid Refractory Acute GVHD Treated with IL-2 & TNF-alpha Blocker in a Myelodysplastic Syndrome Patient who Underwent Unrelated Allogeneic Stem Cell Transplantation

Lee HH, Ahn MJ, Choi CU, Park SR, Baek YH, Sohn W, Lee DJ, Chang MH, Choi JH, Lee YY, Kim IS, Park CK

Hematopoietic stem cell transplantation has evolved as a central treatment modality for the management of various hematologic malignancies. Despite adequate posttransplantation immunosuppressive therapy, acute GVHD remains a major cause of...
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Selective Expansion of Natural Killer Cells from Peripheral Blood Mononuclear Cells by K562 Cell Line and IL-2

Cho D, Shin SW, Park JS, Kang HK, Kim SK, Pham TN, Zhu XW, Shin MG, Suh SP, Ryang DW, Nam JH, Kim YJ, Lee JJ

BACKGROUND: Several attempts have been made to expand human NK cells from peripheral blood mononuclear cells (PBMCs). This study examined the selective expansion of NK cells using interleukin 2 (IL-2)...
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Human Activated Lymphocyte Treated with Anti-CD3, CD16, CD56 Monoclonal Antibody and IL-2

Hong SM, Lee DW, Kang JG, Kim HS, Cho SH

BACKGROUND: Throughtout the last three decades, the therapy of leukemias and lymphoma has set the stage for curative cancer therapy in systemic malignant disease. This was the result of an...
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Effects of Enterococcus faecalis sonicated extracts on IL-2, IL-4 and TGF-beta1 production from human lymphocytes

Kim HS, Jang SW, Shon WJ, Lee ST, Kim CH, Lee WC, Lim SS

In order to examine the immunoresponse of host cells to Enterococcus faecalis, this in vitro study monitored the production of Interleukin-2 (IL-2), Interleukin-4 (IL-4) and Transforming growth factor-beta1 (TGF-beta1) in...
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Inhibition of Graft Versus Host Disease Using CD4+ CD25+ T Cells Induced with Interleukin-2 in Mismatched Allogeneic Murine Hematopoietic Stem Cell Transplantation

Hyun JH, Jeong DC, Chung NG, Park SJ, Min WS, Kim TG, Choi BO, Kim WI, Han CW, Kim HK

BACKGROUND: In kidney transplantation, donor specific transfusion may induce tolerance as a result of some immune regulatory cells against the graft. In organ transplantation, the immune state arises from a...
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Evaluation of Tuberculosis Activity in Patients with Anthracofibrosis by Use of Serum Levels of IL-2 sRalpha, IFN-gamma and TBGL(Tuberculous Glycolipid) Antibody

Jeong DY, Cha YJ, Lee BJ, Jung HR, Lee SH, Shin JW, Kim JY, Park IW, Choi BW

  • KMID: 2318420
  • Tuberc Respir Dis.
  • 2003 Sep;55(3):250-256.
BACKGROUND: Anthracofibrosis, a descriptive term for multiple black pigmentation with fibrosis on bronchoscopic examination, has a close relationship with active tuberculosis (TB). However, TB activity is determined in the later...
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Chemotherapy and Low Dose Interleukin-2 Therapy for Acute Myeloid Leukemia in Patient with Down Syndrome

Kim JT, Pai KS, Kim MK, Jung JW, Soh DM

  • KMID: 2278233
  • Korean J Pediatr Hematol Oncol.
  • 2001 Apr;8(1):126-131.
A 4-day-old patient with Down syndrome (DS) visited out patient department (OPD) because of jaundice and VSD. Peripheral blood smear showed 21% of myeloblast. After 4 weeks of observation, WBC...
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Effects of B-16 Melanoma Cells and Mycoplasma pneumoniae on the Induction of IL-1 beta, IL-2, IL-6, IL-10, IL-12, and TNF - alpha from Mouse Astrocytes

Kim TY, Jeon BC, Lee HD, Chang MW

  • KMID: 1621372
  • J Bacteriol Virol.
  • 2001 Mar;31(1):1-10.
No abstract available.
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Combination Gene Therapy Using IL-2 and GM-CSF Genes Transferred by a Defective Infectious Single Cycle Herpes Virus (DISC Virus) in Head and Neck Squamous Cell Cancer Model

Kim SH, Hong WP, Choi EC, Yoon JH, Choi JJ, Yoon HC

  • KMID: 2275629
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 Jan;44(1):71-79.
BACKGROUND AND OBJECTIVES: The Herpes Simplex type 2 Defective Infectious Single Cycle virus (DISC virus) is an attenuated virus originally produced as a viral vaccine, but it also serves as...
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Experimental Otitis Media with Effusion Induced by Interleukin 2

Kim BG, Park YS, Jung DG, Park SY, Yeo SW, Chae SY

  • KMID: 2275620
  • Korean J Otolaryngol-Head Neck Surg.
  • 2001 Jan;44(1):21-25.
BACKGROUND AND OBJECTIVES: The etiology and pathogenesis of otitis media with effusion (OME) have not been fully elucidated, although multiple theories exist. These pathogenic factors are eustachian tube dysfunction, allergy,...
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Serum soluble IL-2 receptor levels following interferon and ribavirin combination therapy with chronic hepatitis C

Lee JY, Yang JW, Park SH, Park CJ, Seo JS, Lee JH, Kim YB, Kim HY, Yoo JY

  • KMID: 2306171
  • Korean J Med.
  • 2000 Nov;59(5):511-515.
BACKGROUND: To evaluate the cellular immune response to interferon(IFN)-alpha and ribavirin combination therapy in patients with chronic hepatitis C, we monitored serum levels of soluble IL-2 receptor(sIL2R) before and after...
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The Levels of Interferon-gamma, Interleukin-2 Receptor, Interleukin-6 and Interleukin-10 in the patients with Malignant Pleural Effusion, Tuberculosis Effusion, Parapneumonic Effusion, and Lung Emphysema?

Kim MH, Kim SJ, Park YK, Kim SC, Lee SY, Kim YK, Kim KH, Moon HS, Song JS, Park SH

BACKGROUND: Cytokines are chemical mediators that control and modulate many infalmmatory processes. They work in different fashions in a variety of diseases. Discriminating between malignant effusion, tuberculous effusion, and parapneumonic...
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Expression of HLA-DR, ICAM-1, IL-2 and IL-4 in Renal Biopsy of Trasplanted Patient

Nam ES, Lee HI, Kim DH, Shin HS, Lee S, Kim JS, Kim ST, Chae DW

  • KMID: 2003712
  • J Korean Soc Transplant.
  • 2000 Jun;14(1):65-74.
PURPOSE: We performed this study to evaluate the value as early markers predicting the acute rejection and differential diagnosis with other causes of renal dysfunction. METHODS: Immunohistochemical stains for HLA-DR,...
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Effects of Low Dose Interleukin-2 Therapy after High Dose Chemotherapy and Autologous PBSCT in Childhood AML and Stage 4 Neuroblastoma

Kim MK, Lyu CJ, Park SH, Cho HS, Yang CH, Kim HM, Kang SH, Kim KY

  • KMID: 1979927
  • Korean J Pediatr Hematol Oncol.
  • 2000 Apr;7(1):82-91.
PURPOSE: Interleukin-2 (IL-2) exerts anti-cancer effect by increasing NK cell activity when the tumor burden is low. Earlier study conducted with high dose intravenous IL-2 exhibited significant toxicities such...
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Clinical applications of interleukin-2

Lee HG

  • KMID: 1551283
  • Korean J Med.
  • 1999 Oct;57(4):453-458.
No abstract available.
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Immunochemotherapy using Interleukin-2, Interferon-alpha, and 5-fluorouracil for Advanced Renal Cell Carcinoma

Lim D, Lee SB, Kim DY, Park MS, Lee SE

  • KMID: 2290365
  • Korean J Urol.
  • 1999 Aug;40(8):957-962.
PURPOSE: The role of immunotherapy in the treatment of patients with advanced renal cell carcinoma(RCC) is being evaluated by a number of investigators. In this study, we evaluated the efficacy...
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