J Korean Pediatr Cardiol Soc.  2006 Jun;10(2):189-195.

The Relationship Between the Serum Level of Cytokines (Interleukin-2, Interleukin-6, Interleukin-10, Interferon-gamma) and the Erythematous Induration of BCG Site in the Children with Kawasaki Disease

• Kim SH
• Huh J
• Kang IS
• Lee HJ

Abstract

PURPOSE: This study was aimed to investigate the clinical findings and the changes of serum levels of inflammatory cytokines according to the presence of erythematous induration at BCG (Bacillus Calmette-Guerin) site in the children with Kawasaki disease.
METHODS
Thirty-one patients with Kawasaki disease were classified into a group with erythematous induration at BCG site (BCG (+), n=14, M: F=11: 3) and a group without skin changes at BCG site (BCG (-), n=17, M: F=12: 5). Levels of various laboratory parameters and cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) were determined four times on admission day, 3-4 days, 2 weeks and 8 weeks after intravenous immunoglobuin injection.
RESULTS
The age of onset in BCG (+) group was significantly younger than BCG (-) group (15+/-8 months vs. 31+/-16 months, P<0.05). There were no significant differences in other clinical findings and laboratory parameters except elevated ESR in BCG (-) group. There was no difference in complications of coronary arteries and cardiac function between two groups. The serum levels of IL-2, IL-6 and IL-10 were increased in all patients at the diagnosis, but there were no significant differences between BCG (-) and BCG (-) groups. The serial changes of cytokines did not show any significant differences.
CONCLUSION
In Kawasaki disease, BCG site injection seems to develop in younger age and not to be related to the differences of immunologic inflammatory response.

Keyword

Kawasaki disease; Cytokine; Bacillus Calmette-Guerin

MeSH Terms

Age of Onset
Child*
Coronary Vessels
Cytokines*
Diagnosis
Humans
Interferon-gamma
Interleukin-10*
Interleukin-2
Interleukin-6*
Mucocutaneous Lymph Node Syndrome*
Mycobacterium bovis*
Skin
Cytokines
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-6