J Korean Neuropsychiatr Assoc.
1997 Jan;36(1):80-84.
The Effect of Haloperidol on Serum Levels of Interleukins in Schizophrenic Patients
- Affiliations
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- 1Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.
Abstract
OBJECTIVE
Altered interleukin(IL) regulation has been regarded as an additional proof that schizophrenia has a viral-autoimmunological background. However, it is possible that abnormalities of ILs may represent a neuroleptic artifact rather than a finding intrinsic to the disorder. Therefore, we studied the effect of haloperidol on serum IL level in schizophrenic patents.
METHODS
We measured seam levels of IL-1beta, IL-2, and IL-6 using quantitative sandwich ELISA method at the day 0(before-medication), week 4 and week 8 in 20 male schizophrenic patents.
RESULTS
There were no significant differences in serum IL-1beta, IL-2, and IL-6 levels between before medication and at either week 4 and week 8 artier haloperidol administration.
CONCLUSIONS
These Bindings suggest that at least 8 weeks of haloperidol administration does not affect serum IL-19, IL-2 and IL-6 levels in male schizophrenics.
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