Korean J Psychopharmacol.  1999 Apr;10(1):65-70.

Effect of Clozapine on Plasma Prolactin Levels in Schizophrenic Patients

Affiliations
  • 1Department of Psychiatry, School of Medicine, Inha University, Inchon, Korea. kce320@inha.ac.kr

Abstract


OBJECTIVE
The purpose of this study was to investigate the effect of clozapine on seam prolactin concentration in schizophrenic patients. METHOD: The subjects composed of 3-schizophrenic patients with hyperprolactinemia after treatment with risperidone and 9-tratment resistant chronic schizophrenic patients. Serum prolactin concentration was measured by radioimmunoassay method before clozapine administration and artier 1 and 4 week of treatment. Data were analysed by the SAS program. Statistical methods employed was Wilcoxon-sign rank test.
RESULTS
1) Clozapine had improving effect on 3 risperidone-induced hyperprolactinemic patients. 2) Clozapine did not have significant effect on serum prolactin levels in 9-tratment resistant chronic schizophrenic patients.
CONCLUSION
Clozapine has minimal effects on serum prolactin levels in schizophrenic patients as well as improving effect on antipsychotics-induced hyperprolactinemia. We recommend atypical antipsychotics such as clozapine as alternative treatments for complicated hyperprolactinemia induced by other antipsychotics.

Keyword

Schizophrenia; Prolactin; Clozapine

MeSH Terms

Antipsychotic Agents
Clozapine*
Humans
Hyperprolactinemia
Plasma*
Prolactin*
Radioimmunoassay
Risperidone
Schizophrenia
Antipsychotic Agents
Clozapine
Prolactin
Risperidone
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