J Korean Neuropsychiatr Assoc.  1998 Mar;37(2):273-279.

The Effect of Methylphenidate and Haloperidol Coadministration in Schizophrenics with Predominant Negative Symptoms by Double-Blind Trial and the Results of 1 Year Follow-up

• Kim BY
• Kim JH
• Kim JJ
• Han YS
• Lee CU
• Lee SJ
• Lee C
• Paik IH

Abstract

OBJECTIVE
This study was designed to examine whether the methylphenidate(MPD) might have an effect on the negative symptoms in schizophrenic patients. METHOD: We administered MPD to 22 schizophrenic patients who had been taking haloperidol(HPD) by double-blind trial for 6 weeks. The scores of PANSS(Positive and Negative symptom Scale) and AIMS(Abnormal Involuntary Movement Scale) and other side effects were compared between the group of MP and HPD coadmistration and that of HPD at baseline and 2, 4 and 6 weeks after. All patients were followed up for the clinical changes 1 year after the study. RESULT: There were not significant differences between the group of MP and HPD coadministration and that of HPD in PANSS, AIMS and other side effects. The clinical scores were not changed in the group of MP and HPD coadministration as well as in that of HPD.
CONCLUSION
These results suggest that MP would not have an effect on the negative symptoms in schizophrenic patients.

Keyword

Methylphenidate; Haloperidol; Schizophrenia; Negative symptom

MeSH Terms

Dyskinesias
Follow-Up Studies*
Haloperidol*
Humans
Methylphenidate*
Schizophrenia
Haloperidol
Methylphenidate