Ann Dermatol.  1993 Jan;5(1):13-16. 10.5021/ad.1993.5.1.13.

Levels of Soluble Interleukin-2 Receptors in Serum of Patients with Behçet's Disease

• Hur W
• Lee SH
• Bang D
• Lee S
• Kim JC
• Chung TH

• KMID: 2361727
• DOI: http://doi.org/10.5021/ad.1993.5.1.13

Abstract

BACKGROUND
Interleukin-2 receptor (IL-2) is expressed and released predominantly activated T lymphocyte. Increased serum levels of soluble IL-2R have been noted in a variety of autoimmune diseases and in conditions associated with T lymphocyte activation.
OBJECTIVE
We aimed to examine whether the T lymphocyte activation has any association with the pathogenesis of Behçet's disease. METHOD: We have measured the serum level of soluble IL-2R in serum samples obtained from 67 patients with Behçet's disease and 30 healthy people as a control group, using a double-antibody sandwich enzyme-linked immunosorbent assay technique.
RESULTS
Serum soluble IL-2R levels were found to be significantly elevated in the group of Behçet's disease as compared with the control group. No significant differences were found within clinical subtypes of Behçet's disease.
CONCLUSION
These findings suggest the presence of an ongoing T lymphocyte activation in this disease process.

Keyword

Behçet's disease; Soluble interleukin-2 receptor

MeSH Terms

Autoimmune Diseases
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-2*
Lymphocyte Activation
Lymphocytes
Methods
Receptors, Interleukin-2*
Interleukin-2
Receptors, Interleukin-2