Korean J Anesthesiol.  2005 Nov;49(5):671-678. 10.4097/kjae.2005.49.5.671.

Effects of Lidocaine and Propofol on Production of Interleukin (IL)-2, IL-4, and Nitric Oxide in Mice

• Chung SR
• Kim JY
• Kim KH
• Chang TH

• KMID: 1936825
• DOI: http://doi.org/10.4097/kjae.2005.49.5.671

Abstract

BACKGROUND: The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice.
METHODS
The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO.
RESULTS
We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures.
CONCLUSIONS
These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.

Keyword

IL-2; IL-4; lidocaine; nitric oxide; propofol

MeSH Terms

Anesthesia
Anesthetics
Animals
Humans
Interleukin-2
Interleukin-4*
Interleukins*
Lidocaine*
Mice*
Nitric Oxide*
Propofol*
Anesthetics
Interleukin-2
Interleukin-4
Interleukins
Lidocaine
Nitric Oxide
Propofol