Korean J Immunol.  1997 Dec;19(4):583-594.

Effects of Alcohol Administration on Cytokines, Nitric Oxide, Infection Anaphylaxis and Melanoma Growth

Abstract

The present study was undertaken to investigate the effect of ethanol administration on the resistance of mice to Cryptococcus neoformans, IL-2 production of murine splenocytes, active systemic anaphylaxis induced by ovalbumin (OVA), serum TNF-alpha production, nitric oxide (NO) production by peritoneal machrophages and B16F10 melanoma colonization in lungs in mice. It was found that ethanol administration significantly inhibited the resistance of mice to C. neoformans infection, IL-2 production, active systemic anaphylaxis induction, serum TNF- alpha production and NO production. Ethanol administration significantly enhanced lung colonization when it was administered before i.v. melanoma inoculation. These results demonstrate that ethanol may play a critical role in tumorigenesis and immunoregulation as an immunomodulator.

Keyword

Alcohol; Cytokines; Anaphylaxis; Nitric oxide; TNF-a; Melanoma

MeSH Terms

Anaphylaxis*
Animals
Carcinogenesis
Colon
Cryptococcus neoformans
Cytokines*
Ethanol
Interleukin-2
Lung
Melanoma*
Mice
Nitric Oxide*
Ovalbumin
Tumor Necrosis Factor-alpha
Cytokines
Ethanol
Interleukin-2
Nitric Oxide
Ovalbumin
Tumor Necrosis Factor-alpha
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